The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex
The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex
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DOI：
10.1016/j.vaccine.2007.11.053
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发表时间：
2008-03-10
期刊：
影响因子：
5.5
通讯作者：
Elbers, Knut
中科院分区：
文献类型：
--
作者：
Fachinger, Vicky;Bischoff, Ralf;Elbers, Knut
本试验旨在研究猪圆环病毒2型（PCV2）疫苗对猪呼吸道疾病复合征（PRDC）的免疫效果。在约20日龄时，将总计1542头猪随机分配至两个处理组。各组通过单次肌内注射接受杆状病毒表达的重组PCV 2开放阅读框架（ORF）2疫苗或安慰剂。PCV 2病毒血症和呼吸体征的中位发作发生在动物18周龄时。疫苗接种使平均PCV 2病毒载量降低55 - 83%（p <0.0001），病毒血症的平均持续时间降低50%（p <0.0001）。学习期间（3至25周龄）接种疫苗的动物显示死亡率降低（6.63% vs. 8.67%，差异-2.04%; p = 0.1507），平均日增重改善（649 g/天对667 g/天;差异+18 g/天; p <0.0001）和上市时间缩短（164.8天对170.4天;差异-5.6天; p <0.0001）。在PCV 2病毒血症发作和结束饲养之间的8周期间，对性能的影响最大。这些数据表明，单独接种抗PCV 2疫苗可显著改善猪在多因素、迟发性疾病复合体（如PRDC）中的总体生长性能。(c)2008年由Elsevier Ltd.出版
A field study was conducted to investigate the effect of vaccination against porcine circovirus type 2 (PCV2) in pigs suffering from porcine respiratory disease complex (PRDC). A total of 1542 pigs were allocated randomly into two treatment groups at approximately 20 days of age. Groups received either a Baculovirus-expressed recombinant PCV2 Open Reading Frame (ORF) 2 vaccine or placebo by single intramuscular injection. Median onset of PCV2 viraemia and respiratory signs occurred when animals were 18 weeks old. Vaccination reduced the mean PCV2 viral load by 55-83% (p < 0.0001) and the mean duration of viraemia by 50% (p < 0.0001). During the period of study (from 3 to 25 weeks of age) vaccinated animals exhibited a reduced mortality rate (6.63% vs. 8.67%, difference -2.04%; p=0.1507), an improved average daily weight gain (649 g/day vs. 667 g/day; difference +18 g/day; p < 0.0001) and a reduced time to market (164.8 days vs. 170.4 days; difference -5.6 days; p < 0.0001). The effects on performance were greatest in the 8-week period between the onset of PCV2 viraemia and the end of finishing. These data demonstrate that vaccination against PCV2 alone can significantly improve the overall growth performance of pigs in a multi-factorial, late occurring disease complex such as PRDC. (c) 2008 Published by Elsevier Ltd.