Effect of age on cerebral blood flow: Measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults
Effect of age on cerebral blood flow: Measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults
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DOI：
10.1148/radiology.209.3.9844657
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发表时间：
1998-12-01
期刊：
影响因子：
19.7
通讯作者：
Mali, WPTM
中科院分区：
文献类型：
--
作者：
Buijs, PC;Krabbe-Hartkamp, MJ;Mali, WPTM
目的：确定采用非门控二维相位对比磁共振（MR）血管造影测量的全脑血流量（CBF）的正常值以及年龄和性别对其的影响。
材料与方法：对250名因非脑血管疾病指征而接受MR成像的受试者（年龄范围19 - 88岁，平均年龄50岁）的二维相位对比MR血管造影片中的基底动脉以及双侧颈内动脉的血流量进行测量。将这三条动脉的血流量相加得到全脑血流量，并根据年龄和性别对数值进行分析。
结果：平均全脑血流量为616 mL/min ± 143。全脑血流量随年龄每年显著下降4.8 mL/min（P <.001）。19 - 29岁和80 - 89岁受试者的平均全脑血流量分别为748 mL/min ± 121和474 mL/min ± 105。未发现性别差异。右侧和左侧颈内动脉以及基底动脉对全脑血流量的平均相对贡献率分别为41%、40%和19%，且不因年龄而有实质性变化。
结论：非门控二维相位对比MR血管造影是一种用于评估全脑血流量的有用的无创技术。通过使用该技术，证实了全脑血流量随年龄显著下降。
PURPOSE: To determine the normal values and effects of age and sex on total cerebral blood flow (CBF) as measured with ungated two-dimensional phase-contrast magnetic resonance (MR) angiography.MATERIALS AND METHODS: Volume flow rates in the basilar artery and both internal carotid arteries were measured on two-dimensional phase-contrast MR angiograms obtained in 250 subjects(age range, 19-88 years; mean age, 50 years) undergoing MR imaging because of indications other than cerebrovascular disease. Volume flow rates for-the th ree arteries were sum med to obtain the total CBF, and the values were analyzed in terms of age and sex.RESULTS: Mean total CBF was 616 mL/min +/- 143. There was a significant yearly decrease with age in total CBF of 4.8 mL/min (P < .001). Mean total CBF ranged from 748 mL/min +/- 121 to 474 mL/min +/- 105 in subjects aged 19-29 and 80-89 years respectively. No sex differences were found. Mean relative contributions of the right and left internal carotid arteries and the basilar artery to total CBF were 41%, 40% and 19%, respectively, with no substantial change due to age.CONCLUSION: Ungated two-dimensional phase-contrast MR angiography is a useful, noninvasive technique for assessing total CBF. By using this technique, a significant decrease in total CBF with age was demonstrated.