Volumetric measurements of the cerebrospinal fluid spaces in demented subjects and controls.
Volumetric measurements of the cerebrospinal fluid spaces in demented subjects and controls.
复制标题
对痴呆受试者和对照组的脑脊液空间进行体积测量。
作者：
M. Gado;C. P. Hughes;W. Danziger;D. Chi;G. Jost;L. Berg
47名受试者65至80岁，其中20名痴呆和27名正常，进行了研究的计算机断层扫描。心室体积指数（V%）和脑沟大小（S%）通过像素计数确定，而不了解临床状态。对照组的V%为5.30（+/- 1.92），痴呆受试者为10.46（+/- 4.78）。对照组的S%为6.14（+/- 2.51），痴呆受试者的S%为10.61（+/- 3.32）。在每种情况下，两组之间的差异均具有显著性（P <0.0001）。当使用线性和体积测量分析29次扫描的子样本时，线性测量显示痴呆受试者和对照组之间的差异不太明显。这些发现解释了不同研究人员关于痴呆症和正常衰老中心室和脑沟大小变化的相互矛盾的结果。
Forty-seven subjects 65 to 80 years of age, of whom 20 were demented and 27 were normal, were studied by computed tomography. Volumetric indices of ventricular (V%) and sulcal size (S%) were determined by pixel counts without knowledge of clinical status. V% was 5.30 (+/- 1.92) for the controls and 10.46 (+/- 4.78) for the demented subjects. S% was 6.14 (+/- 2.51) for the controls and 10.61 (+/- 3.32) for the demented subjects. In each case, differences between the two groups were significant (P less than 0.0001). When a subsample of 29 scans were analyzed using linear and volumetric measurements, the linear measurements showed less pronounced differences between the demented subjects and the controls. These findings explain the conflicting results of different investigators concerning variations in ventricular and sulcal size in dementia and normal aging.