Elevated basal FSH in normal cycling women is associated with unfavourable lipid levels and increased cardiovascular risk
Elevated basal FSH in normal cycling women is associated with unfavourable lipid levels and increased cardiovascular risk
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DOI：
10.1093/humrep/deg330
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发表时间：
2003-08-01
影响因子：
6.1
通讯作者：
Taylor, HS
中科院分区：
文献类型：
--
作者：
Chu, MC;Rath, KM;Taylor, HS
背景：心血管疾病是女性死亡的主要原因，大多数死亡发生在绝经后。人们一直认为，缺乏雌激素是导致女性心血管疾病的主要因素。然而，最近使用激素替代疗法治疗女性心血管疾病的试验并没有肯定这种疗法对心血管的好处。在接近更年期的几十年里，卵巢功能缓慢下降，表现为生育力下降，血清FSH上升，抑制素下降，但雌二醇水平正常。我们调查了基础FSH与心血管疾病的主要危险因素之间的关系。方法和结果：我们获得了40名年龄在29岁到49岁之间、月经周期正常、没有使用激素药物或他汀类药物的妇女的第3天血清FSH水平和空腹脂蛋白谱。绝经前卵泡刺激素水平高于或等于7IU/L的绝经前妇女，总胆固醇(P=0.009)和低密度脂蛋白(P=0.019)显著高于卵泡刺激素
BACKGROUND: Cardiovascular disease is the leading cause of death in women, with most deaths occurring after menopause. It had been assumed that lack of estrogen is a leading contributing factor to cardiovascular disease in women. Recent trials, however, using hormone replacement therapy to treat cardiovascular disease in women have not affirmed the cardiovascular benefits ascribed to this regimen. Ovarian function declines slowly over the decades approaching the menopause as evidenced by declining fertility, rising serum FSH, falling inhibin, yet normal estradiol levels. We investigated the relationship between basal FSH and an established major risk factor for cardiovascular disease. METHODS AND RESULTS: We obtained cycle day 3 serum FSH levels and fasting lipoprotein profiles on 40 women between the ages of 29 and 49 years, with normal menstrual cycles and who were not using hormonal medications or statins. Premenopausal women with an FSH level greater than or equal to7 IU/l had significantly elevated total cholesterol (P = 0.009) and LDL (P = 0.019) compared with those with FSH