No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle
No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle
复制标题
DOI：
10.1152/ajpendo.00300.2005
复制
发表时间：
2006-01-01
影响因子：
5.1
通讯作者：
Kjaer, M
中科院分区：
文献类型：
--
作者：
Miller, BF;Hansen, M;Kjaer, M
月经周期对收缩骨骼肌肌原纤维和结缔组织蛋白合成无影响。美国生理学杂志内分泌代谢290：E163-E168，2006年。首次出版于2005年8月30日; doi：10.1152/ajpendo. 00300.2005.-我们测试的假设，急性运动会刺激合成的肌原纤维蛋白和肌内胶原蛋白的妇女和月经周期的阶段，在运动发生会影响变化的程度。15名年轻健康的女性受试者进行了研究，在卵泡期（FP，n = 8）或黄体期（LP，n = 7，n = 1的相位）24小时后，急性回合的单腿运动（60分钟的踢在67% W-max），样本取自股外侧肌在两个运动和休息的腿。肌原纤维和肌肉胶原蛋白的合成率通过掺入[C-13]亮氨酸来测量。肌原纤维蛋白质合成（平均值+/- SD;静息FP：0.053 +/- 0.009%/ h，LP：0.055 +/- 0.013%/h）在运动后24小时增加（FP：0.131 +/- 0.018%/h，P < 0.05，LP：0.134 +/- 0.018%/ h，P < 0.05），各阶段之间无差异。同样，肌肉胶原蛋白的合成（静息FP：0.024 +/- 0.017%/h，LP：0.021 +/- 0.006%/h）在运动后24小时升高（FP：0.073 +/- 0.016%/h，P < 0.05，LP：0.072 +/- 0.015%/ h，P < 0.05），但月经期之间的反应没有差异。因此，月经周期阶段，在休息或在一个急性回合的运动，对妇女的肌原纤维蛋白质合成和肌肉胶原蛋白合成没有影响。
No effect of menstrual cycle on myofibrillar and connective tissue protein synthesis in contracting skeletal muscle. Am J Physiol Endocrinol Metab 290: E163-E168, 2006. First published August 30, 2005; doi: 10.1152/ajpendo. 00300.2005.-We tested the hypothesis that acute exercise would stimulate synthesis of myofibrillar protein and intramuscular collagen in women and that the phase of the menstrual cycle at which the exercise took place would influence the extent of the change. Fifteen young, healthy female subjects were studied in the follicular (FP, n = 8) or the luteal phase (LP, n = 7, n = 1 out of phase) 24 h after an acute bout of one-legged exercise (60 min of kicking at 67% W-max), samples being taken from the vastus lateralis in both the exercised and resting legs. Rates of synthesis of myofibrillar and muscle collagen proteins were measured by incorporation of [C-13] leucine. Myofibrillar protein synthesis (means +/- SD; rest FP: 0.053 +/- 0.009%/ h, LP: 0.055 +/- 0.013%/h) was increased at 24-h postexercise (FP: 0.131 +/- 0.018%/h, P < 0.05, LP: 0.134 +/- 0.018%/ h, P < 0.05) with no differences between phases. Similarly, muscle collagen synthesis (rest FP: 0.024 +/- 0.017%/h, LP: 0.021 +/- 0.006%/h) was elevated at 24-h postexercise (FP: 0.073 +/- 0.016%/h, P < 0.05, LP: 0.072 +/- 0.015%/ h, P < 0.05), but the responses did not differ between menstrual phases. Therefore, there is no effect of menstrual cycle phase, at rest or in response to an acute bout of exercise, on myofibrillar protein synthesis and muscle collagen synthesis in women.