What doesn't kill them makes them stronger: an association between elongation factor 1-α overdominance in the sea star Pisaster ochraceus and "sea star wasting disease".
What doesn't kill them makes them stronger: an association between elongation factor 1-α overdominance in the sea star Pisaster ochraceus and "sea star wasting disease".
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DOI：
10.7717/peerj.1876
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发表时间：
2016
期刊：
影响因子：
2.7
通讯作者：
Schiebelhut LM
中科院分区：
文献类型：
--
作者：
Wares JP;Schiebelhut LM
近年来，北美太平洋沿岸沿着发生了一场大规模的死亡事件，导致数百万不同种类的海星死亡。这种疾病被称为“海星星星消耗病”（SSWD），与病毒感染有关。在一个受影响的星星（Pisaster ochraceus），以前的工作已经确定，延伸因子1-α基因座（EF 1A）含有一个内含子插入等位基因，当纯合子时是致命的，但似乎通过增加杂合子的适应性在种群中保持中等频率。支持这种适应性增加的环境条件尚不清楚，但过度显性通常与疾病有关。在这里，我们评估的群体P.赭色，以确定SSWD和EF 1A基因型之间的关系。我们的数据表明，可能有显着降低发生SSWD的个人是杂合在这个位点。这些结果表明，进一步的研究是必要的，以了解在EF 1A的多样性和生存P.赭色之间的功能关系。
In recent years, a massive mortality event has killed millions of sea stars, of many different species, along the Pacific coast of North America. This disease event, known as ‘sea star wasting disease’ (SSWD), is linked to viral infection. In one affected sea star (Pisaster ochraceus), previous work had identified that the elongation factor 1-α locus (EF1A) harbored an intronic insertion allele that is lethal when homozygous yet appears to be maintained at moderate frequency in populations through increased fitness for heterozygotes. The environmental conditions supporting this increased fitness are unknown, but overdominance is often associated with disease. Here, we evaluate populations of P. ochraceus to identify the relationship between SSWD and EF1A genotype. Our data suggest that there may be significantly decreased occurrence of SSWD in individuals that are heterozygous at this locus. These results suggest further studies are warranted to understand the functional relationship between diversity at EF1A and survival in P. ochraceus.