The association analysis of hOGG1 genetic variants and gastric cancer risk in a Chinese population.
The association analysis of hOGG1 genetic variants and gastric cancer risk in a Chinese population.
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hOGG1基因变异与中国人群胃癌风险的关联分析
DOI：
10.18632/oncotarget.11802
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发表时间：
2016-10-04
期刊：
影响因子：
--
通讯作者：
Zhang Z
中科院分区：
文献类型：
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作者：
Lu J;Yin Y;Du M;Ma G;Ge Y;Zhang Q;Chu H;Tong N;Wang M;Qiu J;Zhang Z
已知人8-氧代鸟嘌呤DNA糖基化酶（hOGG 1）在预防包括胃癌（GC）在内的癌发生中起重要作用。我们进行了一项病例对照研究，以探讨是否单核苷酸多态性（SNPs）的hOGG 1与GC的风险在中国人群。两个潜在的功能tagSNP（rs 159153和rs 1052133）和先前报道的风险SNP（rs 125701）在1,275例GC患者和1,436例对照中进行了基因分型。我们发现SNP rs 125701 G > A与GC风险增加显著相关[相加模型中调整的比值比（OR）= 1.38，95%置信区间（CI）= 1.05-1.79]。此外，功能研究表明rs 125701的A等位基因显著降低hOGG 1启动子的转录活性，提高cg 15357639的CpG位点甲基化水平。结论：hOGG 1基因启动子rs 125701多态性与胃癌易感性相关，可作为胃癌易感性的一个新的生物标志物。rs 125701在胃癌发病机制中的功能有待进一步验证。
Human 8-oxoguanine DNA glycosylase (hOGG1) is known to play an important role in the prevention of carcinogenesis, including gastric cancer (GC). We performed a case-control study to investigate whether single nucleotide polymorphisms (SNPs) of hOGG1 are associated with GC risk in a Chinese population. Two potential functional tagSNPs (rs159153 and rs1052133) and a previously reported risk SNP (rs125701) were genotyped in 1,275 GC patients and 1,436 controls. We found that SNP rs125701 G > A was significantly associated with the increased GC risk [adjusted odds ratio (OR) = 1.38, 95% confidence interval (CI) = 1.05-1.79 in additive model]. Besides, the functional studies demonstrated that the minor A allele of rs125701 significantly reduced the transcriptional activity of hOGG1 promoter and enhanced the methylation level of CpG site of cg15357639. In conclusion, our results suggested that the SNP rs125701 in hOGG1 promoter was associated with the elevated GC risk, which could act as a new potential biomarker for GC susceptibility. Further functional verification of rs125701 in GC pathogenesis is warranted.