COPD and stroke: are systemic inflammation and oxidative stress the missing links?
COPD and stroke: are systemic inflammation and oxidative stress the missing links?
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DOI：
10.1042/cs20160043
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发表时间：
2016-07-01
期刊：
影响因子：
--
通讯作者：
Vlahos R
中科院分区：
文献类型：
--
作者：
Austin V;Crack PJ;Bozinovski S;Miller AA;Vlahos R
慢性阻塞性肺疾病（COPD）的特征在于进行性气流受限和肺功能丧失，并且是目前世界上第三大死亡原因。目前已明确心血管相关合并症（如卒中）可导致COPD的发病率和死亡率。COPD和中风之间的联系机制尚未完全明确，但可能相互关联。COPD与中风之间的关联可能在很大程度上取决于共同的风险因素，例如衰老和吸烟，或者COPD与传统中风风险因素的关联。此外，我们认为COPD相关的全身炎症和氧化应激可能通过促进脑血管功能障碍和血小板高活性而发挥重要作用。在这篇综述中，我们简要讨论了COPD的发病机制，COPD急性加重（AECOPD）和与COPD相关的心血管合并症，特别是中风。我们还强调并讨论了支持COPD和中风之间联系的潜在机制，特别关注全身炎症和氧化应激的作用。
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest cause of death in the world. It is now well established that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as aging and smoking, or the association of COPD with traditional stroke risk factors. In addition, we propose that COPD-related systemic inflammation and oxidative stress may play important roles by promoting cerebral vascular dysfunction and platelet hyperactivity. In this review, we briefly discuss the pathogenesis of COPD, acute exacerbations of COPD (AECOPD) and cardiovascular comorbidities associated with COPD, in particular stroke. We also highlight and discuss the potential mechanisms underpinning the link between COPD and stroke, with a particular focus on the roles of systemic inflammation and oxidative stress.