Coronary hemodynamics and cardiac beating modulate atrial natriuretic factor release from isolated Langendorff-perfused rat hearts.
Coronary hemodynamics and cardiac beating modulate atrial natriuretic factor release from isolated Langendorff-perfused rat hearts.
复制标题
冠状动脉血流动力学和心脏跳动调节离体 Langendorff 灌注大鼠心脏的心房钠尿因子释放。
DOI：
10.1016/0024-3205(87)90217-7
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发表时间：
1987
期刊：
影响因子：
6.1
通讯作者：
Shizume,K
中科院分区：
文献类型：
--
作者：
Naruse,M;Higashida,T;Naruse,K;Shibasaki,T;Demura,H;Inagami,T;Shizume,K
在离体Langendorff灌流的大鼠心脏上研究了冠状动脉血流动力学和心脏搏动对心钠素（ANF）释放的作用。放射免疫法测定心钠素释放。当冠脉流量改变时，心钠素释放呈流量依赖性减少或增加。当灌注压改变时，ANF释放也分别增加或减少，伴随着冠状动脉流速的变化。此外，灌注50 mM氯化钾显示立即心脏骤停和心钠素释放减少到不可检测的水平，冠状动脉流量显着减少。然而，低，但容易检测到的心钠素释放量时，冠状动脉血流速度保持。这些结果提示冠状动脉血流动力学和心脏搏动可能是心房分泌ANF的调节因素。
The role of coronary hemodynamics and cardiac beating on atrial natriuretic factor (ANF) release was studied in the isolated Langendorff-perfused rat heart. ANF release was measured by radioimmunoassay. When the coronary flow rate was changed, ANF release decreased or increased in a flow-dependent manner. When the perfusion pressure was changed, ANF release also increased or decreased, respectively, with concomitant changes in coronary flow rate. Furthermore, perfusion with 50 mM potassium chloride showed immediate cardiac arrest and a decrease of ANF release to an undetectable level with a significant decrease in coronary flow. However, low but readily detectable amounts of ANF were released when coronary flow rate was maintained. These results may suggest that coronary hemodynamics and cardiac beating could be factors modulating ANF secretion from the atrium.