Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression
Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression
复制标题
有证据表明 HTR1A 和 LHPP 是重度抑郁症中相互影响的遗传风险因素
DOI：
10.1038/mp.2008.8
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发表时间：
2009-06-01
影响因子：
11
通讯作者：
Katz, D. A.
中科院分区：
文献类型：
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作者：
Neff, C. D.;Abkevich, V.;Katz, D. A.
HTR 1A-1019 C>G基因型与犹他州人群中的抑郁症相关。对有严重抑郁症家族史的犹他州家系（仅包括HTR 1A-1019 G等位基因的病例）进行连锁分析，发现10号染色体上有一个连锁峰（最大HLOD=4.4）。所有已知的基因在连锁区的测序揭示疾病分离的单核苷酸多态性（SNP）在LHPP。在犹他州和德系犹太人中，LHPP单核苷酸多态性也与重度抑郁症相关。与连锁证据一致，LHPP关联依赖于HTR 1A基因型。因此，Lhpp或共线脑特异性转录产物可能在抑郁症的发病机制中与Htr 1a相互作用。Molecular Psychiatry（2009）14，621-630; doi：10.1038/mp.2008.8; 2008年2月12日在线发表
The HTR1A -1019C>G genotype was associated with major depression in the Utah population. Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the HTR1A -1019G allele revealed a linkage peak on chromosome 10 (maximum HLOD=4.4). Sequencing of all known genes in the linkage region revealed disease-segregating single-nucleotide polymorphisms (SNPs) in LHPP. LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations. Consistent with the linkage evidence, LHPP associations depended on HTR1A genotype. Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression. Molecular Psychiatry (2009) 14, 621-630; doi:10.1038/mp.2008.8; published online 12 February 2008