Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing
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DOI：
10.2147/ijn.s106662
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发表时间：
2016-06
影响因子：
8
通讯作者：
Lu Wen;Pei Zeng;Liping Zhang;Wenli Huang;Hui Wang;Gang Chen
中科院分区：
文献类型：
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作者：
Lu Wen;Pei Zeng;Liping Zhang;Wenli Huang;Hui Wang;Gang Chen
本研究首次利用具有抗炎和抑菌活性的中草药兰科植物内生真菌合成了银纳米颗粒（AgNPs）。通过各种表征技术对AgNP进行分析，以揭示其形态、化学组成和稳定性。首次研究了中草药、内生真菌与银纳米粒子性质的关系。有趣的是，在这项研究中进行的一项实验揭示了内生真菌产生的蛋白质被覆盖在纳米颗粒上，这导致了球形和多分散的AgNP的稳定性增加，具有低聚集性超过6个月。更重要的是，进一步的研究表明，AgNPs具有上级抗菌活性，并能有效促进伤口愈合。综上所述，利用中草药内生真菌生物合成活性AgNPs具有简单、生态友好的优点，具有广阔的应用前景。
In this study, silver nanoparticles (AgNPs) were synthesized for the first time using an antibacterial endophytic fungus of Chinese medicinal herb Orchidantha chinensis, which has anti-inflammatory and antimicrobial activities. The AgNPs were analyzed by various characterization techniques to reveal their morphology, chemical composition, and stability. Also, the relationship between Chinese medicinal herbs, endophytic fungi, and the property of AgNPs was investigated for the first time. Interestingly, an experiment performed in this study revealed the proteins produced by the endophytic fungus to be capped on the nanoparticles, which led to an increase in the stability of spherical and polydispersed AgNPs with low aggregation for over 6 months. More importantly, further study demonstrated that the AgNPs possessed superior antibacterial activity and effectively promoted wound healing. Altogether, the biosynthesis of active AgNPs using the endophytic fungus from Chinese medicinal herb based on the symbiosis theory is simple, eco-friendly, and promising.