Effects of social manipulations and environmental enrichment on behavior and cell-mediated immune responses in rhesus macaques
Effects of social manipulations and environmental enrichment on behavior and cell-mediated immune responses in rhesus macaques
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DOI：
10.1016/s0091-3057(02)00779-7
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发表时间：
2002-08-01
影响因子：
3.6
通讯作者：
Schapiro, SJ
中科院分区：
文献类型：
--
作者：
Schapiro, SJ
本文综述了一系列研究，考察了对社会和无生命环境的操纵对生活在不同环境中的不同年龄的恒河猴的行为和细胞免疫反应的影响。总的来说，用玩具、结构、觅食设备和/或录像带丰富无生命的环境增加了猴子表现出的物种典型行为的数量，但不影响它们的免疫反应。另一方面，在社会性地安置猴子，不仅导致花在典型物种活动上的时间增加，而且还导致(1)花在异常行为上的时间减少，(2)一些免疫参数发生变化。此外，试图直接影响社交寄养成年恒河猴的附属相互作用已经导致了附属行为的系统性变化，尽管预期的伴随细胞介导的免疫反应的系统性变化尚未实现。这些数据表明，在缺乏其他实验操作的情况下，物理和社会环境的各个方面会影响圈养猕猴的行为和免疫学参数。因此，需要适当地管理和/或控制这些影响，以便最大限度地减少实验设计中的潜在混淆。(C)2002 Elsevier Science Inc.保留所有权利。
This paper reviews a series of studies that have examined the effects of manipulations to the social and the inanimate environments on the behavior and cell-mediated immune responses of rhesus macaques of various ages living in different settings. In general, enrichment of the inanimate environment with toys, structures, foraging devices, and/or videotapes increased the amount of species-typical behavior expressed by the monkeys, but did not affect their immune responses. Housing monkeys socially, on the other hand, not only resulted in increased time spent in species-typical activities, but also resulted in (1) decreases in time spent in abnormal behavior and (2) changes in a number of immune parameters. Additionally, attempts to directly influence the affiliative interactions of socially housed adult rhesus have resulted in systematic changes in affiliative behavior, although anticipated accompanying systematic alterations to cell-mediated immune responses have yet to be realized. The data suggest that aspects of the physical and social environments influence behavioral and immunological parameters in captive macaques in the absence of other experimental manipulations. As such, these influences need to be appropriately managed and/or controlled in order to minimize potential confounds in experimental designs. (C) 2002 Elsevier Science Inc. All rights reserved.