Pan-cancer analyses of Jab1/COPS5 reveal oncogenic role and clinical outcome in human cancer.
Pan-cancer analyses of Jab1/COPS5 reveal oncogenic role and clinical outcome in human cancer.
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Jab1/COPS5 的泛癌分析揭示了人类癌症中的致癌作用和临床结果
DOI：
10.1016/j.heliyon.2022.e12553
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发表时间：
2022-12
期刊：
影响因子：
4
通讯作者：
Pan, Yunbao
中科院分区：
文献类型：
--
作者：
Wang, Liping;Zeng, Xiaojiao;Yang, Gui;Liu, Guohong;Pan, Yunbao
Jab1/COPS5与一些癌症的进展有关，然而，它在大多数癌症中的作用尚不清楚。本研究在大量临床资料的基础上，系统探讨了Jab1/COPS5在不同肿瘤中的作用及临床应用价值。基于TCGA、GEO和CPTAC数据库，我们首先通过差异和生存分析发现，Jab1/COPS5在大多数癌症中作为高风险基因高表达，并且与患者的预后生存密切相关。突变分析表明，错义突变是Jab1的主要突变类型。在大多数肿瘤中，TMB和MSI与Jab1/COPS5呈正相关，且Jab1/COPS5突变的前列腺癌患者预后较差。免疫浸润分析发现，在胸腺瘤和葡萄膜黑色素瘤中，Jab1/COPS5表达与CD8+ T细胞浸润呈正相关，在睾丸生殖细胞肿瘤中，Jab1/COPS5表达与癌相关成纤维细胞浸润呈负相关。相关富集分析表明，ARMC1、TCEB1和UBE2V2与Jab1/COPS5表达呈正相关，参与多种生物学效应。综上所述，本研究系统探讨了Jab1/COPS5在不同肿瘤中的作用，为Jab1/COPS5在未被研究的肿瘤中作为新的生物标志物提供了理论基础，为靶向治疗和药物开发铺平了道路。Jab1 / COPS5;肿瘤突变负荷；免疫渗透;微卫星不稳定性;预后。
Jab1/COPS5 is associated with the progression of some cancers, however, its role in most cancers is still unclear.This study systematically explored the action and clinical application value of Jab1/COPS5 in different tumors based on large clinical data. We first identified by differential and survival analysis that Jab1/COPS5 was highly expressed as a high-risk gene in most cancers and was closely related to prognostic survival of patients based on the TCGA, GEO and CPTAC databases. Mutation analysis suggested that missense mutations were the main mutation type of Jab1. TMB and MSI were positively correlated with Jab1/COPS5 in most tumors, and patients with Jab1/COPS5 mutations had a poorer prognosis in prostate adenocarcinoma. By immune infiltration analysis, Jab1/COPS5 expression was positively correlated with the infiltration of CD8+ T cells in thymoma and uveal melanoma, and Jab1/COPS5 expression in testicular germ cell tumors was negatively correlated with the infiltration of cancer-associated fibroblasts. Correlation and enrichment analysis suggested that ARMC1, TCEB1 and UBE2V2 were positively correlated with Jab1/COPS5 expression and involved in multiple biological effects. In summary, this study systematically investigated the role of Jab1/COPS5 in different tumors, providing a theoretical basis for Jab1/COPS5 as a new biomarker in unresearched cancers and paving the way for targeted therapy and drug development. Jab1/COPS5; tumor mutational burden; immune infiltration; microsatellite instability; prognosis.
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影响因子：
254.7
作者：
Miller, Kimberly D.;Fidler-Benaoudia, Miranda;Siegel, Rebecca L.
通讯作者：
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影响因子：
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作者：
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通讯作者：
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