CD5+ diffuse large B-cell lymphoma with c-myc/IgH rearrangement presenting as primary effusion lymphoma
CD5+ diffuse large B-cell lymphoma with c-myc/IgH rearrangement presenting as primary effusion lymphoma
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DOI：
10.1532/ijh97.04155
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发表时间：
2005-05-01
影响因子：
2.1
通讯作者：
Ozawa, T
中科院分区：
文献类型：
--
作者：
Fujisawa, S;Tanioka, F;Ozawa, T
我们报告一例弥漫性大B细胞淋巴瘤，表现为急性心力衰竭。一位69岁的人类免疫缺陷病毒阴性的男子被收住到我们医院的全身疲劳。胸部和腹部的计算机断层扫描显示心包积液，但没有肿瘤肿块、淋巴结肿大或肝脾肿大的证据。化疗期间出现乳酸脱氢酶升高和胸腔积液。积液中的肿瘤细胞显示CD 5、CD 19、CD 20、kappa链和Bcl-2阳性，而CD 10和CD 23阴性。染色体t（8;14）（q24;q32）伴c-myc/免疫球蛋白（IG）H重排，MIB-1指数不高（60%）。聚合酶链反应检测细胞中既未检测到人类疱疹病毒8型，也未检测到EB病毒DNA。对化疗的反应非常差，患者在诊断后4个月死亡。CD 5（+）淋巴瘤的一系列症状包括心包积液，也可伴有c-myc/IgH重排。(c)2005日本血液学会。
We report an instructive case of diffuse large B-cell lymphoma presenting as acute heart failure. A 69-year-old human immunodeficiency virus-negative man was admitted to our hospital for general fatigue. A computed tomographic scan of the chest and abdomen showed pericardial effusion, but there was no evidence of tumor masses, lymph node enlargement, or hepatosplenomegaly. During the chemotherapy, increased lactate dehydrogenase and pleural effusion appeared. The tumor cells in the effusion showed positivity for CD5, CD19, CD20, kappa chain, and Bcl-2 and negativity for CD10 and CD23. The chromosomes showed t(8;14)(q24;q32) with c-myc/immunoglobulin (Ig)H rearrangement, and the MIB-1 index was not high (60%). Neither human herpes virus 8 nor Epstein-Barr virus DNA was detected in the cells by polymerase chain reaction. The response to chemotherapy was very poor, and the patient died 4 months after the diagnosis. A spectrum of the symptoms of CD5(+) lymphoma encompasses pericardial effusion and also can accompany c-myc/IgH rearrangement. (c) 2005 The Japanese Society of Hematology.