EFFECTS OF VASODILATING AGENTS ON COCHLEAR BLOOD-FLOW IN MICE
EFFECTS OF VASODILATING AGENTS ON COCHLEAR BLOOD-FLOW IN MICE
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DOI：
10.1016/0378-5955(94)90115-5
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发表时间：
1994-11-01
期刊：
影响因子：
2.8
通讯作者：
MILLER, JM
中科院分区：
文献类型：
--
作者：
NAKASHIMA, T;NUTTALL, AL;MILLER, JM
小鼠作为研究哺乳动物耳蜗血流（CBF）的实验模型具有几个明显的优势，特别是对于涉及遗传操作、发育和衰老因素的研究。在这项调查中，我们评估了选定的血管扩张剂对CBF的影响，使用激光多普勒血流仪。硝普钠、肼苯哒嗪和喷替福林局部应用于圆窗（RW）或通过皮下注射全身应用。局部应用硝普钠和肼苯哒嗪可显著升高CBF，而全身应用这两种药物未能持续升高CBF。喷替福林局部给药后没有改变CBF，但全身给药后CBF略有增加。年龄和性别不影响局部应用硝普钠对CBF的反应。
The mouse has several distinct advantages as an experimental model for study of the cochlear blood flow (CBF) in the mammal, particularly for studies involving genetic manipulation, development and aging factors. In this investigation we evaluated the effects of selected vasodilating agents on CBF using laser-Doppler flowmetry. Sodium nitroprusside, hydralazine and pentoxifylline were applied topically on the round window (RW) or systemically by a subcutaneous injection. Topical application of sodium nitroprusside and hydralazine elevated CBF significantly, while systemic administrations of these two drugs failed to elevate CBF consistently. Pentoxifylline did not change CBF following topical application but increased CBF slightly following systemic administration. Age and gender did not influence the CBF response to topical application of sodium nitroprusside.