Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets.
Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets.
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前列腺癌的超级增强子：转录障碍和治疗靶点
DOI：
10.1038/s41698-020-00137-0
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发表时间：
2020-11-19
影响因子：
7.9
通讯作者：
Niu Y
中科院分区：
文献类型：
--
作者：
Chen X;Ma Q;Shang Z;Niu Y
致癌和抑癌信号通路的异常活动与人类的癌症和癌症风险有关。这些途径的转录失调通常与肿瘤的发生和癌症的发展有关。遗传和表观遗传改变可能介导转录活性失调。最重要的表观遗传学变化之一是非编码调控元件，它包括增强子和超级增强子(SE)。SES的特征是大量的增强子与异常高水平的转录因子结合，被认为是控制和维持癌细胞特性的基因表达的关键驱动因素。在癌细胞中，癌基因获得SES，癌症表型依赖于这些由SES驱动的异常转录程序，这导致癌细胞经常对SES相关的转录程序上瘾，包括前列腺癌。在此，我们综述了SES及其相关基因调控前列腺癌的最新研究成果，并对基础研究和临床试验中潜在的药理抑制剂进行了综述。
Abnormal activity of oncogenic and tumor-suppressor signaling pathways contributes to cancer and cancer risk in humans. Transcriptional dysregulation of these pathways is commonly associated with tumorigenesis and the development of cancer. Genetic and epigenetic alterations may mediate dysregulated transcriptional activity. One of the most important epigenetic alternations is the non-coding regulatory element, which includes both enhancers and super-enhancers (SEs). SEs, characterized as large clusters of enhancers with aberrant high levels of transcription factor binding, have been considered as key drivers of gene expression in controlling and maintaining cancer cell identity. In cancer cells, oncogenes acquire SEs and the cancer phenotype relies on these abnormal transcription programs driven by SEs, which leads to cancer cells often becoming addicted to the SEs-related transcription programs, including prostate cancer. Here, we summarize recent findings of SEs and SEs-related gene regulation in prostate cancer and review the potential pharmacological inhibitors in basic research and clinical trials.
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影响因子：
37.3
作者：
Donati B;Lorenzini E;Ciarrocchi A
通讯作者：
Ciarrocchi A
人 TFIIH 激酶 CDK7 调节转录相关的染色质修饰。
影响因子：
8.8
作者：
Ebmeier CC;Erickson B;Allen BL;Allen MA;Kim H;Fong N;Jacobsen JR;Liang K;Shilatifard A;Dowell RD;Old WM;Bentley DL;Taatjes DJ
通讯作者：
Taatjes DJ
影响因子：
82.9
作者：
Dai X;Gan W;Li X;Wang S;Zhang W;Huang L;Liu S;Zhong Q;Guo J;Zhang J;Chen T;Shimizu K;Beca F;Blattner M;Vasudevan D;Buckley DL;Qi J;Buser L;Liu P;Inuzuka H;Beck AH;Wang L;Wild PJ;Garraway LA;Rubin MA;Barbieri CE;Wong KK;Muthuswamy SK;Huang J;Chen Y;Bradner JE;Wei W
通讯作者：
Wei W
影响因子：
5.3
作者：
Chen, Hongjie;Kichaev, Gleb;Lindstrom, Sara
通讯作者：
Lindstrom, Sara
影响因子：
5.6
作者：
Baumgart SJ;Haendler B
通讯作者：
Haendler B