Physical activity and colon cancer: A public health perspective
Physical activity and colon cancer: A public health perspective
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DOI：
10.1016/s1047-2797(96)00129-9
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发表时间：
1997-02-01
影响因子：
5.6
通讯作者：
Potter, JD
中科院分区：
文献类型：
--
作者：
Slattery, ML;Edwards, SL;Potter, JD
目的：有人建议，在一周中的大多数日子里，至少进行30分钟的体育锻炼可以改善健康。这项研究的目的是评估体育锻炼与结肠癌的关系，因为它与这一公共卫生建议有关。方法：进行了一项基于人群的结肠癌病例对照研究。研究参与者来自美国三个地区：加利福尼亚州北部、犹他州和明尼苏达州的双子城大都市区。结果：长期参与高水平的运动，相当于每节课大于或等于60分钟的剧烈运动，与风险降低相关(优势比[OR]，0.68；95%可信区间[CI]0.52-0.87)。参与活动的时间似乎比每周进行活动的天数影响更大。与久坐不动的人相比，那些报告活动水平最高的人，根据持续时间和剧烈运动强度的定义，风险最低(OR，0.62；95%CI，0.52-0.75)；诊断年龄、结肠肿瘤部位或性别之间的相关性没有差异。在那些没有结直肠癌家族史的人中，结肠癌与长期活跃的休闲活动之间的负关联略强于那些有结直肠癌家族史的人。根据这些数据，我们估计13%的结肠癌可以归因于人们缺乏活跃的休闲活动；我们估计每年每10万人中有4.3例结肠癌病例被预防，因为人们参与了激烈的休闲体育活动。结论：这项研究的数据表明，过去20年进行的高水平的活跃的休闲活动对降低结肠癌风险很重要；在过去20年中，当每一次活动的时间更长时，观察到最大的负相关关系。这些数据和其他数据表明，重要的是要找出促进人口中增加闲暇时间体育活动的方法。(C)1997年，爱思唯尔科学公司。
PURPOSE: It has been suggested that performing physical activity for at least 30 min on most days of the week will improve health. The purpose of this study was to assess the association between physical activity and colon cancer as it relates to this public health recommendation.METHODS: A large population-based case-control study of colon cancer was conducted. Study participants came from three areas of the United States: Northern California, Utah, and the Twin Cities Metropolitan Area in Minnesota.RESULTS: Long-term involvement in high levels of activity, equivalent to greater than or equal to 60 min of vigorous activity per session, was associated with decreased risk (odds ration [OR], 0.68; 95% confidence interval [CI] 0.52-0.87). The amount of time involved in the activity appeared to have a greater impact than the number of days per week that activities were performed. Those reporting the highest level of activity, as defined by both duration and vigorous intensity, were at the lowest risk (OR, 0.62; 95% CI, 0.52-0.75) relative to those who were sedentary; associations did not differ by age at diagnosis, site of the tumor within the colon, or sex. The inverse association between colon cancer and long-term vigorous leisure-time activity was slightly stronger among those without a family history of colorectal cancer than among those with a family history of colorectal cancer. From these data we estimate chat 13% of colon cancer could be attributed to lack of vigorous leisure-time activity in the population; we estimate that 4.3 cases of colon cancer/100,000 population are prevented each year because people are involved in Vigorous leisure time physical activity.CONCLUSIONS: Data from this study suggest that a high level of vigorous leisure-time activity performed over the past 20 years was important in reducing colon cancer risk; the greatest inverse association was observed when activities were performed for longer periods of time per session for the past 20 years. These and other data indicate that it is important to identify ways to facilitate an increase in leisure-time physical activity within the population. (C) 1997 by Elsevier Science Inc.