Oxidant and antioxidant status in coronary artery disease
Oxidant and antioxidant status in coronary artery disease
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DOI：
10.3892/br.2018.1130
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发表时间：
2018-10-01
影响因子：
2.3
通讯作者：
Karimi-Busheri, Feridoun
中科院分区：
文献类型：
--
作者：
Bastani, Abdolhossein;Rajabi, Sadegh;Karimi-Busheri, Feridoun
动脉粥样硬化斑块的形成是冠状动脉疾病（CAD）的主要原因。多项研究揭示了氧化应激在冠心病发病机制中的作用。本研究的目的是研究冠心病患者和对照人群的氧化和抗氧化标志物。研究样本包括急性冠脉综合征（ACS）患者、慢性冠心病患者和健康对照组（n=30/组）。采集患者和对照组血液，测定还原性谷胱甘肽（GSH）、丙二醛（MDA）浓度及MDA释放率，测定血浆红细胞谷胱甘肽过氧化物酶（GPx）活性和总抗氧化能力（TAC）。采用分光光度法测定各项参数。此外，比较单支、双支或三支血管狭窄的冠心病患者及其对照组的氧化/抗氧化状态。结果表明，MDA水平和MDA释放率显著升高(P
Formation of atherosclerotic plaques is the major cause of coronary artery disease (CAD). Several lines of study have revealed the role of oxidative stress in CAD pathogenesis. In the present study the aim was to investigate the oxidative and antioxidative markers in CAD patients and a control population. The study sample comprised of acute coronary syndrome (ACS) patients, chronic CAD patients and healthy controls (n=30/group). Blood samples of patients and control subjects were collected to measure the concentrations of reduced glutathione (GSH), malondialdehyde (MDA) and the percentage of MDA release as well as the activity of erythrocyte glutathione peroxidase (GPx) and total antioxidant capacity (TAC) of plasma. All parameters were measured by spectrophotometric methods. Additionally, oxidant/antioxidant status was compared between CAD patients with single, double or triple-vessel stenosis and in comparison with controls. The results indicated a significant increase in MDA level and the percentage of MDA release (P