Targeting the Microenvironment in Esophageal Cancer.
Targeting the Microenvironment in Esophageal Cancer.
复制标题
针对食管癌的微环境
DOI：
10.3389/fcell.2021.684966
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Qin Y
中科院分区：
文献类型：
--
作者：
Wang L;Han H;Wang Z;Shi L;Yang M;Qin Y
食管癌（EC）是第八种最常见的癌症类型，也是全球癌症相关死亡的第六大原因。目前，临床上对EC的治疗主要以根治性手术、化疗和放疗为主。然而，由于常规治疗的疗效有限，且不良反应严重，其结果仍不理想（患者的5年生存率低于25%）。因此，寻找新的治疗靶点显得极其重要和紧迫。肿瘤微环境（TME）的概念自提出以来，引起了越来越多的关注。最近的研究表明，TME是EC的重要治疗靶点。免疫治疗、抗血管生成治疗等微环境靶向治疗在延长食管癌患者生存期、改善预后方面发挥了不可或缺的作用。此外，许多针对微环境开发的新药和疗法可能成为未来的治疗选择。本文就EC的微环境及微环境靶向治疗的最新进展作一综述。
Esophageal cancer (EC) is the eighth most common type of cancer and the sixth leading cause of cancer-related deaths worldwide. At present, the clinical treatment for EC is based mainly on radical surgery, chemotherapy, and radiotherapy. However, due to the limited efficacy of conventional treatments and the serious adverse reactions, the outcome is still unsatisfactory (the 5-year survival rate for patients is less than 25%). Thus, it is extremely important and urgent to identify new therapeutic targets. The concept of tumor microenvironment (TME) has attracted increased attention since it was proposed. Recent studies have shown that TME is an important therapeutic target for EC. Microenvironment-targeting therapies such as immunotherapy and antiangiogenic therapy have played an indispensable role in prolonging survival and improving the prognosis of patients with EC. In addition, many new drugs and therapies that have been developed to target microenvironment may become treatment options in the future. We summarize the microenvironment of EC and the latest advances in microenvironment-targeting therapies in this review.
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影响因子：
5.2
作者：
Augustin RC;Delgoffe GM;Najjar YG
通讯作者：
Najjar YG
影响因子：
--
作者：
Chen MF;Kuan FC;Yen TC;Lu MS;Lin PY;Chung YH;Chen WC;Lee KD
通讯作者：
Lee KD
影响因子：
3.3
作者：
Bhushan, Ashish;Singh, Avninder;Saxena, Sunita
通讯作者：
Saxena, Sunita
影响因子：
3.7
作者：
Akutsu, Yasunori;Hanari, Naoyuki;Matsubara, Hisahiro
通讯作者：
Matsubara, Hisahiro
DOI：
10.1016/s1470-2045(20)30109-1
发表时间：
2020-05
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Abou-Alfa GK;Sahai V;Hollebecque A;Vaccaro G;Melisi D;Al-Rajabi R;Paulson AS;Borad MJ;Gallinson D;Murphy AG;Oh DY;Dotan E;Catenacci DV;Van Cutsem E;Ji T;Lihou CF;Zhen H;Féliz L;Vogel A
通讯作者：
Vogel A