Relationship between active and passive smoking and total serum IgE levels in Japanese women: Baseline data from the Osaka maternal and child health study
Relationship between active and passive smoking and total serum IgE levels in Japanese women: Baseline data from the Osaka maternal and child health study
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DOI：
10.1159/000081307
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发表时间：
2004-01-01
影响因子：
2.8
通讯作者：
Oda, H
中科院分区：
文献类型：
--
作者：
Miyake, Y;Miyamoto, S;Oda, H
背景：许多研究表明，吸烟与血清总IgE浓度升高有关。然而，很少有研究检查总IgE与被动吸烟暴露的关系，特别是在成人中。这项横断面研究调查了日本主动和被动吸烟暴露与血清总IgE水平的关系。研究对象为大坂市981名孕妇。使用UniCAP 1000测量总IgE水平，如果超过170 ml/UI，则定义为升高。年龄、妊娠、产次、哮喘、特应性湿疹和过敏性鼻炎家族史、室内家养宠物、家庭收入、教育程度和室内灰尘中螨变应原水平被选为潜在混杂因素。结果如下：目前每天吸烟至少15支和吸烟8.0包年或以上与血清总IgE升高的患病率增加独立相关（调整后的比值比分别为3.40和2.51，95%置信区间分别为2.12-5.47和1.55-4.06），吸烟状况和吸烟包年数与血清总IgE水平显著正相关，尤其是在有阳性家族过敏史的受试者中。在从不吸烟的人中，在家中或工作中暴露于环境烟草烟雾（ETS）与血清总IgE浓度之间没有可测量的关联。结论：我们的研究结果证实了积极吸烟和血清总IgE水平之间的正相关关系，但是，这项研究未能证实ETS暴露与总IgE呈正相关。有必要进行更精确和详细的暴露测量。版权所有（C）2004 S. Karger AG，巴塞尔。
Background: Many studies have shown that cigarette smoking is associated with elevated concentrations of total serum IgE. Few studies, however, have examined total IgE in relation to passive smoking exposure, especially in adults. This cross-sectional study investigated the association of active and passive smoking exposure with levels of total serum IgE in Japan. Methods: Study subjects were 981 pregnant women in Osaka. Total IgE levels were measured using UniCAP 1000 and were defined as elevated if they exceeded 170 ml/UI. Age, gestation, parity, family history of asthma, atopic eczema and allergic rhinitis, indoor domestic pets, family income, education and the mite allergen level in house dust were selected as potential confounding factors. Results: Current smoking of at least 15 cigarettes a day and 8.0 or more pack-years of smoking were independently related to an increased prevalence of elevated total serum IgE (adjusted odds ratios 3.40 and 2.51, 95% confidence intervals 2.12-5.47 and 1.55-4.06, respectively), and both cigarette smoking status and pack-years of smoking were significantly positively associated with total serum IgE levels, especially in subjects with a positive familial allergic history. There was no measurable association of exposure to environmental tobacco smoke (ETS) at home or at work with total serum IgE concentrations among those who had never smoked. Conclusions: Our results corroborate a positive relationship between active smoking and total serum IgE levels; however, this study failed to substantiate a positive association of ETS exposure with total IgE. Investigations with more precise and detailed exposure measurements are warranted. Copyright (C) 2004 S. Karger AG, Basel.