Hippocampal functional connectivity-based discrimination between bipolar and major depressive disorders
Hippocampal functional connectivity-based discrimination between bipolar and major depressive disorders
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基于海马功能连接的双相情感障碍和重度抑郁症之间的区分
DOI：
10.1016/j.pscychresns.2019.01.004
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发表时间：
2019-02-28
影响因子：
2.3
通讯作者：
Chen, Huafu
中科院分区：
文献类型：
--
作者：
Fateh, Ahmed Ameen;Long, Zhiliang;Chen, Huafu
尽管在心境障碍的神经病理学方面取得了令人印象深刻的进展，但双相情感障碍（BD）患者在最初表现为重度抑郁障碍（MDD）时经常被误诊。在神经影像学研究的支持下，海马的异常功能连接（FC）与各种心境障碍（包括BD和MDD）相关。然而，尚未直接比较MDD和BD的海马FC特征。本研究旨在研究海马静息状态FC（rsFC）分析，以区分这两种临床条件。收集30例BD患者、29例MDD患者和30例健康对照者的静息态功能磁共振成像（fMRI）数据，采用单因素方差分析（One-way ANOVA）评估所有受试者海马FC的潜在差异。BD患者的双侧前/后海马、舌回和额下回（IFG）的FC相对于MDD患者增加。与HC相比，BD和MDD患者的右侧前海马与舌回之间的FC增加，右侧后海马与右侧IFG之间的FC减少，结果显示MDD患者的海马FC明显高于BD患者。这些发现可能有助于研究人员试图通过使用功能磁共振成像数据来区分情绪障碍。
Despite the impressive advancements in the neuropathology of mood disorders, patients with bipolar disorder (BD) are often misdiagnosed on the initial presentation with major depressive disorder (MDD). With supporting evidence from neuroimaging studies, the abnormal functional connectivity (FC) of the hippocampus has been associated with various mood disorders, including BD and MDD. However, the features of the hippocampal FC underlying MDD and BD have not been directly compared. This study aims to investigate the hippocampal resting-state FC (rsFC) analyses to distinguish these two clinical conditions. Resting-state functional magnetic resonance imaging (fMRI) data was collected from a sample group of 30 patients with BD, 29 patients with MDD and 30 healthy controls (HCs).One-way ANOVA was employed to assess the potential differences of the hippocampus FC across all subjects. BD patients exhibited increased FC of the bilateral anterior/posterior hippocampus with lingual gyrus and inferior frontal gyrus (IFG) relative to patients MDD patients. In comparison with HCs, patients with BD and MDD had an increased FC between the right anterior hippocampus and lingual gyrus and a decreased FC between the right posterior hippocampus and right IFG.The results revealed a distinct hippocampal FC in MDD patients compared with that observed in BD patients. These findings may assist investigators in attempting to distinguish mood disorders by using fMRI data.