Determination of plasma glucose during rapid glucose excursions with a subcutaneous glucose sensor.
Determination of plasma glucose during rapid glucose excursions with a subcutaneous glucose sensor.
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DOI：
10.1089/152091503763816436
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发表时间：
2003-01-01
影响因子：
5.4
通讯作者：
Saad, Mohammed F
中科院分区：
文献类型：
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作者：
Steil, Garry M;Rebrin, Kerstin;Saad, Mohammed F
动态血糖监测有可能改善糖尿病患者的血糖管理并降低低血糖风险。精确的传感器还可以允许开发闭环胰岛素输送系统。这项工作的目的是确定在快速变化的葡萄糖波动期间与皮下葡萄糖传感器相关的延迟时间。皮下葡萄糖传感器（Medtronic MiniMed，Inc.，Northridge，CA）插入5名健康男性。在2小时稳定期后，进行3小时高血糖（约11 mM）钳夹，然后进行90分钟钳夹，使血糖降至2.8 mM。使用两个点（基础和高血糖）校准探头，并将校准的探头葡萄糖测量值与参考分析仪（Beckman Instruments，Fullerton，CA）的测量值进行比较。响应时间从一阶动力学模型估计。用皮下传感器测定的血浆葡萄糖水平与用参考葡萄糖分析仪测定的血浆葡萄糖水平高度相关（r（2）= 0.91，p < 0.001;平均绝对差约为8%）。传感器响应的半衰期估计为4.0 +/- 1.0 min。当用于实时监测时，皮下葡萄糖传感器有可能促进低血糖检测并改善总体血糖控制。快速响应应足以允许基于皮下传感部位开发全自动闭环胰岛素输送系统。
Continuous glucose monitoring has the potential to improve glucose management and reduce the risk of hypoglycemia in individuals with diabetes. Accurate sensors may also allow the development of a closed-loop insulin delivery system. The purpose of this work was to determine the delay time associated with a subcutaneous glucose sensor during rapidly changing glucose excursions. Subcutaneous glucose sensors (Medtronic MiniMed, Inc., Northridge, CA) were inserted in five healthy men. After a 2-h stabilization period, a 3-h hyperglycemic (approximately 11 mM) clamp was performed followed by a 90-min period in which plasma glucose was allowed to decline to as low as 2.8 mM. Sensors were calibrated using two points (basal and hyperglycemia), and the calibrated sensor glucose measurements were compared with those from a reference analyzer (Beckman Instruments, Fullerton, CA). Response time was estimated from a first-order kinetic model. Plasma glucose levels, determined with the subcutaneous sensor, were highly correlated with those obtained with the reference glucose analyzer (r(2) = 0.91, p < 0.001; mean absolute difference of approximately 8%). The half-time for the sensor response was estimated to be 4.0 +/- 1.0 min. The subcutaneous glucose sensor has the potential to facilitate the detection of hypoglycemia and improve overall glycemic control when used in a real-time monitor. The rapid response should be sufficient to allow a fully automated closed-loop insulin delivery system to be developed based on the subcutaneous sensing site.