The role of branched chain amino acids metabolic disorders in tumorigenesis and progression
The role of branched chain amino acids metabolic disorders in tumorigenesis and progression
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DOI：
10.1016/j.biopha.2022.113390
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Qiuhong Duan
中科院分区：
文献类型：
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作者：
Jingtong Wang;Wei Wang;Feng Zhu;Qiuhong Duan
Branched-chain amino acids (BCAAs) are essential amino acids in human bodies. They have complex metabolic pathways and various metabolites. Both BCAAs and its metabolites are involved in various processes such as protein anabolism and catabolism, energy supply, signaling transduction and so on. Previous studies have observed the widely alternations of BCAAs and its related proteins in multiple tumor phenotypes, which suggests that BCAAs metabolic disorders may have emerged as a powerful factor for tumor metabolism reprogramming. BCAAs metabolism has a pivotal role in tumorigenesis and progression, including cell growth, proliferation, migration, invasion, and so on. In this review, we try to shed light on the crucial role of BCAAs metabolic disorders in different tumor types by focusing on the impacts of metabolic disorders of BCAAs and discussing the notable proteins involved in cancer metabolic reprogramming of BCAAs, such as BCAT1/2, BCKDH-BCKDK-PPM1K complex, transporters of BCAAs and its metabolites, transcription factors and so on, and present several possible diagnose approaches and therapies to BCAAs-related cancers. • BCAAs and its metabolites promote tumor growth. • BCAAs-related proteins are associated with tumor genesis and development. • Environment, diet and genetic variations can affect BCAAs metabolism. • Targeting BCAAs can be used as the basis for tumor diagnosis and targeted therapy.
