Self-reported sleep and β-amyloid deposition in community-dwelling older adults.
Self-reported sleep and β-amyloid deposition in community-dwelling older adults.
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DOI：
10.1001/jamaneurol.2013.4258
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发表时间：
2013-12
期刊：
影响因子：
29
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Spira, Adam P.;Gamaldo, Alyssa A.;An, Yang;Wu, Mark N.;Simonsick, Eleanor M.;Bilgel, Murat;Zhou, Yun;Wong, Dean F.;Ferrucci, Luigi;Resnick, Susan M.
老年人通常报告睡眠障碍，最近对人类和动物的研究表明睡眠与阿尔茨海默病生物标志物之间存在联系。需要研究评估睡眠变量是否与β淀粉样蛋白沉积的神经影像学证据相关。确定社区老年人自我报告的睡眠参数与β-淀粉样蛋白沉积之间的关系。巴尔的摩老龄化的横断面纵向研究，一项对70名成年人进行的规范性老龄化前瞻性研究（平均年龄= 76岁;范围53 - 91）在BLSA神经成像研究中β-淀粉样蛋白负荷，通过[11 C]匹兹堡化合物B（PiB）正电子发射断层扫描（PET）分布体积比（DVR）测量。在调整潜在混杂因素后，睡眠时间短的报告与β淀粉样蛋白负荷增加有关，通过平均皮质DVR测量（cDVR; B = 0.08，95%置信区间（CI）0.03，0.14，p = 0.005）和楔前叶DVR（B = 0.11，95% CI 0.03，0.18，p = 0.007）。睡眠质量较低的报告与楔前叶DVR测量的β-淀粉样蛋白负荷较大相关（B = 0.08，95% CI 0.01，0.15，p = 0.025）。在社区居住的老年人中，睡眠时间较短和睡眠质量较低的报告与更大的β-淀粉样蛋白负担有关。需要进一步研究客观的睡眠测量来确定睡眠障碍是否会导致或加速阿尔茨海默病。
Older adults commonly report disturbed sleep, and recent studies in humans and animals suggest links between sleep and Alzheimer disease biomarkers. Studies are needed that evaluate whether sleep variables are associated with neuroimaging evidence of β-amyloid deposition. To determine the association between self-reported sleep parameters and β-amyloid deposition in community-dwelling older adults. cross-sectional Baltimore Longitudinal Study of Aging, a prospective study of normative aging 70 adults (mean age = 76; range 53 - 91) in the BLSA neuroimaging study β-amyloid burden, measured by [11C] Pittsburgh compound B (PiB) positron emission tomography (PET) distribution volume ratios (DVR) After adjustment for potential confounders, reports of shorter sleep duration were associated with greater β-amyloid burden, measured by mean cortical DVR (cDVR; B = 0.08, 95% confidence interval (CI) 0.03, 0.14, p = 0.005) and precuneus DVR (B = 0.11, 95% CI 0.03, 0.18, p = 0.007). Reports of lower sleep quality were associated with greater β-amyloid burden measured by precuneus DVR (B = 0.08, 95% CI 0.01, 0.15, p = 0.025). Among community-dwelling older adults, reports of shorter sleep duration and lower sleep quality are associated with greater β-amyloid burden. Further studies with objective sleep measures are needed to determine whether sleep disturbance causes or accelerates Alzheimer disease.
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DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
简单的范式去除外部组织：算法和分析。
影响因子：
5.7
作者：
Carass, Aaron;Cuzzocreo, Jennifer;Wheeler, M. Bryan;Bazin, Pierre-Louis;Resnick, Susan M.;Prince, Jerry L.
通讯作者：
Prince, Jerry L.
影响因子：
16.2
作者：
Kamenetz, F;Tomita, T;Malinow, R
通讯作者：
Malinow, R
影响因子：
10.6
作者：
Bazin, Pierre-Louis;Pham, Dzung L.
通讯作者：
Pham, Dzung L.
影响因子：
17.1
作者：
Roh JH;Huang Y;Bero AW;Kasten T;Stewart FR;Bateman RJ;Holtzman DM
通讯作者：
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