Study of Polydiacetylene-Poly (Ethylene Oxide) Electrospun Fibers Used as Biosensors
Study of Polydiacetylene-Poly (Ethylene Oxide) Electrospun Fibers Used as Biosensors
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DOI：
10.3390/ma9030202
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发表时间：
2016-03-01
期刊：
影响因子：
3.4
通讯作者：
Li, Yan Vivian
中科院分区：
文献类型：
--
作者：
Alam, A. K. M. Mashud;Yapor, Janet P.;Li, Yan Vivian
聚丁二炔（PDA）是一种具有良好生物传感性能的共轭材料，它能在外界刺激下发生由蓝到红的颜色变化。以10，12-二十五碳二炔酸（PCDA）和聚环氧乙烷（PEO）为原料，采用静电纺丝技术，在不同的PEO/PCDA质量比、溶液浓度和注射速度下制备纤维复合材料。在紫外光照射下，通过光聚合得到蓝相的PEO-PDA纤维。PEO与PCDA的高质量比、纺丝溶液的低聚合物浓度和低注射速度促进具有小直径和光滑表面的细纤维。当纤维在25 ℃至120 ℃的温度范围内加热时，研究了纤维的色度转变。当纤维在高于60 ℃的温度下加热时，观察到纤维中从蓝色到红色的颜色转换。由于纤维中PDA的高分数，在用低质量比的PEO与PCDA制成的纤维中颜色转变更敏感。大直径光纤由于光纤中的高反射率区域也促进了颜色切换。采用傅里叶变换红外光谱（FT-IR）和差示扫描量热法（DSC）对所有纤维进行了分析，并对颜色变化发生前后进行了比较。提出了由于PDA大分子的构象变化而发生的比色过渡机制。
Polydiacetylene (PDA) is an attractive conjugated material for use in biosensors due to its unique characteristic of undergoing a blue-to-red color change in response to external stimuli. 10,12-Pentacosadiynoic acid (PCDA) and poly (ethylene oxide) (PEO) were used in this study to develop fiber composites via an electrospinning method at various mass ratios of PEO to PCDA, solution concentrations, and injection speeds. The PEO-PDA fibers in blue phase were obtained via photo-polymerization upon UV-light irritation. High mass ratios of PEO to PCDA, low polymer concentrations of spinning solution, and low injection speeds promoted fine fibers with small diameters and smooth surfaces. The colorimetric transition of the fibers was investigated when the fibers were heated at temperatures ranging from 25 degrees C to 120 degrees C. A color switch from blue to red in the fibers was observed when the fibers were heated at temperatures greater than 60 degrees C. The color transition was more sensitive in the fibers made with a low mass ratio of PEO to PCDA due to high fraction of PDA in the fibers. The large diameter fibers also promoted the color switch due to high reflectance area in the fibers. All of the fibers were analyzed using Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) and compared before and after the color change occurred. The colorimetric transitional mechanism is proposed to occur due to conformational changes in the PDA macromolecules.