Disrupted gamma-band neural oscillations during coherent motion perception in heavy cannabis users.
Disrupted gamma-band neural oscillations during coherent motion perception in heavy cannabis users.
复制标题
重度大麻使用者的连贯运动感知过程中伽马带神经振荡被破坏。
DOI：
10.1038/npp.2014.166
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
O'Donnell,BrianF
中科院分区：
文献类型：
--
作者：
Skosnik,PatrickD;Krishnan,GiriP;D'Souza,DeepakC;Hetrick,WilliamP;O'Donnell,BrianF
以前在动物和人类中的研究表明，外源性大麻素会破坏时间锁定的诱发伽马振荡（30-80 Hz）。然而，迄今为止还没有研究检查大麻对非时间锁定的影响，在更复杂的完形感知过程中诱导伽马振荡。因此，目前的研究利用脑电图（EEG）来检查重度大麻使用者和对照组在连贯运动感知过程中的伽马振荡。对慢性大麻使用者（n= 24;研究前12小时戒断;阳性11-去甲-9-羧基-δ-9-四氢大麻酚尿液水平）和大麻初治对照组（n= 23）进行了评价。刺激包括随机点运动图（RDK），受试者被动地在三种不同的条件下观看：连贯运动，不连贯运动和静态。采用基于傅立叶变换的平均尝试功率（MTP）对EEG数据进行时频分析。还评估了刺激开始（视觉N100和P200分量）的瞬时事件相关电位（ERP）。结果表明，与非相干运动和静态条件相比，相干运动条件在伽马范围内（诱导功率从40至59 Hz）产生了神经活动的稳健增加。正如预测的那样，大麻组在相干条件下相对于健康对照组显示出诱导伽马功率的显著降低。在N100或P200成分中，未观察到组间差异，表明初级感觉处理完整。最后，大麻使用者表现出查普曼知觉偏差量表（PAS）分数增加的趋势，这与大麻使用的总年限呈正相关。这些数据表明，大麻的使用可能会干扰诱导的γ-波段神经振荡的产生，这可能在一定程度上介导外源性大麻素的感知改变作用。
Previous work in animals and humans has shown that exogenous cannabinoids disrupt time-locked, evoked gamma oscillations (30–80 Hz). However, no studies to date have examined the effect of cannabis on non-time-locked, induced gamma oscillations during more complex Gestalt perception. The current study therefore utilized electroencephalography (EEG) to examine gamma oscillations during coherent motion perception in heavy cannabis users and controls. Chronic cannabis users (n= 24; 12 h abstinence before study; positive 11-nor-9-carboxy-delta-9-tetrahydrocannabinol urine levels) and cannabis-naive controls (n= 23) were evaluated. Stimuli consisted of random dot kinetograms (RDKs) that subjects passively viewed during three different conditions: coherent motion, incoherent motion, and static. Time× frequency analysis on EEG data was performed using Fourier-based mean trial power (MTP). Transient event-related potentials (ERPs) to stimulus onset (visual N100 and P200 components) were also evaluated. The results showed that the coherent motion condition produced a robust increase in neural activity in the gamma range (induced power from 40 to 59 Hz) as compared with the incoherent motion and static conditions. As predicted, the cannabis group showed significant reductions in induced gamma power in the coherent condition relative to healthy controls. No differences were observed between the groups in the N100 or P200 components, indicating intact primary sensory processing. Finally, cannabis users showed a trend toward increased scores on the Chapman Perceptual Aberration Scale (PAS) that was positively correlated with total years of active cannabis use. These data suggest that cannabis use may interfere with the generation of induced gamma-band neural oscillations that could in part mediate the perceptual-altering effects of exogenous cannabinoids.