Immune response to a single bout of exercise in young and elderly subjects
Immune response to a single bout of exercise in young and elderly subjects
复制标题
DOI：
10.1016/s0047-6374(97)00130-9
复制
发表时间：
1998-01-30
影响因子：
5.3
通讯作者：
Esler, M
中科院分区：
文献类型：
--
作者：
Mazzeo, RS;Rajkumar, C;Esler, M
本研究的目的是探讨淋巴细胞增殖活性和T细胞亚群的变化后，急性发作的运动在年轻和老年人的主题。6名年轻（26 +/- 3岁）和9名老年（69 +/- 5岁）男性受试者在休息时和在50%峰值工作能力下亚极量运动20分钟后立即进行测试。从留置导管中采集动脉血进行儿茶酚胺和免疫学测定。分离外周血淋巴细胞用于有丝分裂原诱导的植物血凝素（PHA）增殖能力。采用双标记流式细胞术分析淋巴细胞亚群。如先前的研究所示，与年轻受试者相比，老年受试者的基线增殖反应性显著较低（向下箭头为22%）。在次极量运动中，年轻受试者对PHA的增殖反应性显著增加（向上箭头55%），然而，对于老年受试者，这种反应与静息值无显著差异（向上箭头18%）。与年轻人相比，老年人静息时的总淋巴细胞数量以及CD 4（+）和CD 8（+）T细胞亚群较低。在不同年龄组中，化疗诱导的T细胞亚群增加相似。得出的结论是，虽然具有较低的初始T细胞数量和PHA反应性，但与年轻个体相比，在单次运动期间的免疫反应性通常在老年人中维持。(C)1998爱思唯尔科学爱尔兰有限公司
The purpose of this investigation was to examine alterations in lymphocyte proliferation activity and T cell subsets following an acute bout of exercise in young and old subjects. Six young (26 +/- 3 years) and nine old (69 +/- 5 years) male subjects were tested at rest and immediately after 20 min of submaximal exercise at 50% peak work capacity. Arterial blood was sampled from an indwelling catheter for catecholamine and immunology assays. Peripheral blood lymphocytes were isolated for mitogen-induced phytohemagglutinin (PHA) proliferation capacity. Lymphocyte subsets were analyzed by dual-labeled flow cytometry. As has been shown in previous studies, baseline proliferative responsiveness was significantly lower in the old (down arrow 22%) compared to the young subjects. In response to submaximal exercise, proliferative responsiveness to PHA increased significantly in the young subjects (up arrow 55%), however, for the old subjects this response did not differ significantly from resting values (up arrow 18%). The number of total lymphocytes, as well as CD4(+) and CD8(+) T cell subsets, at rest were lower for old subjects compared with young. Exercise-induced increases in T cell subset populations were similar across age groups. It was concluded that, while having lower initial T cell numbers and PHA responsiveness, immunoresponsiveness during a single bout of exercise is, in general, maintained in old when compared to young individuals. (C) 1998 Elsevier Science Ireland Ltd.