Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat
Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat
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DOI：
10.1016/s0006-8993(02)03693-4
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发表时间：
2002-12-27
期刊：
影响因子：
2.9
通讯作者：
Mitchell, JL
中科院分区：
文献类型：
--
作者：
Aicher, SA;Sharma, S;Mitchell, JL
孤束核（NTS）尾侧部的AMPA型谷氨酸受体对内脏兴奋性传入（包括压力感受器）的反应至关重要。免疫细胞化学结合电镜观察发现，不同AMPA受体亚单位在尾侧孤束核的细胞分布是不同的。GluR 2/3被发现在突触前和突触后的网站，并在星形胶质细胞胶质细胞，而GluR 1被发现主要在小树突和棘，在双标记的研究中，GluR 1和GluR 2共定位在大树突。而GluR 1在树突棘中单独表达较多。因此。孤束核中的单个神经元含有这两种亚基，但GluR 1向突触可塑性潜在位点的运输存在差异。(C)2002 Elsevier Science B. V.保留所有权利。
AMPA-type glutamate receptors in the caudal portions of nucleus of the solitary tract (NTS) are critical for responses to excitatory afferents from the viscera, including baroreceptors. Using immunocytochemistry combined with electron microscopy, the cellular distributions of different AMPA receptor subunits in the caudal NTS were found to be distinct. GluR2/3 was found at pre- and postsynaptic sites, and in astrocytic glia; while GluR1 was found primarily in small dendrites and spines, In dual-labeling studies, GluR1 and GluR2 were co-localized in large dendrites. but GluR1 was more often found alone in dendritic spine,,. Therefore. single neurons in the NTS contain both subunits, but there is differential trafficking of GluR1 to potential sites for synaptic plasticity. (C) 2002 Elsevier Science B.V. All rights reserved.