ALL-TRANS-RETINOIC ACID-INDUCED VARIANT PATTERNS OF PALATAL RUGAE IN CRJ-SD RAT FETUSES AND THEIR POTENTIAL AS INDICATORS FOR TERATOGENICITY
ALL-TRANS-RETINOIC ACID-INDUCED VARIANT PATTERNS OF PALATAL RUGAE IN CRJ-SD RAT FETUSES AND THEIR POTENTIAL AS INDICATORS FOR TERATOGENICITY
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DOI：
10.1016/0890-6238(95)00024-5
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发表时间：
1995-07-01
影响因子：
3.3
通讯作者：
YASUDA, M
中科院分区：
文献类型：
--
作者：
IKEMI, N;KAWATA, M;YASUDA, M
我们确定了腭裂形成的关键时期，在全反式维甲酸（RA）的存在下，并定义异常模式内的腭皱的变体。在妊娠第13和14天给予40 mg/kg RA的大鼠胎仔中，腭皱变异模式的总发生率显著增加，同时诱导腭裂。对应分析将腭皱的变异模式，如中位数不连续，额外峰，额外皱褶（额外型），缩短，融合和分叉与腭裂联系起来。因此，这些变体被认为是异常的。腭皱异常模式的发生率约为腭裂的10倍，因此，这些异常可能是化学品致畸性的敏感指标。
We determined the critical period for cleft palate formation in the presence of all-trans-retinoic acid (RA) and defined anomalous patterns within the variants of palatal rugae. The total incidence of variant patterns of palatal rugae in rat fetuses treated with RA at 40 mg/kg on gestation days 13 and 14 dramatically increased with concurrent induction of cleft palate, Correspondence analysis connected the variant patterns of palatal rugae, such as median discontinuity, extra peaks, supernumerary ruga (extra type), shortness, fusion, and bifurcation, with cleft palate. Therefore, these variants were concluded to be anomalous. The incidence of the anomalous patterns of palatal rugae was about 10 times that of cleft palate, and consequently, these anomalies might be sensitive indicators of the teratogenicity of a chemical.