Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality.
Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality.
复制标题
野生型 ApoA-II 基因不能挽救加速衰老小鼠 (SAMP1) 的寿命缩短和死亡率加快。
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
K. Higuchi
中科院分区：
文献类型：
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作者：
J. Wang;T. Matsushita;K. Kogishi;C. Xia;A. Ohta;T. Chiba;A. Nakamura;H. Kondo;M. Mori;M. Hosokawa;K. Higuchi
生化和遗传数据表明，载脂蛋白A-II基因的Apoa 2c等位基因导致SAMP 1（一种加速衰老的小鼠模型）中的严重老年性淀粉样变性（AApoAII）。我们分析了用非淀粉样蛋白Apoa 2b替代SAMP 1小鼠中的Apoa 2c对淀粉样变性、脂蛋白代谢和衰老进展的影响，使用同源株P1.R1-Apoa 2b，其在SAMP 1的基因组中具有SAMR 1的Apoa 2b染色体区域。在P1.R1-Apoa 2b中，未观察到apoA-II蛋白和HDL-胆固醇的血浆浓度随年龄增加而降低。P1.R1-Apoa 2b的衰老评分低于SAMP 1。然而，P1.R1-Apoa 2b和SAMP 1的寿命和死亡率倍增时间相似。这些结果表明，用非淀粉样蛋白Apoa 2b替代Apoa 2c不能挽救SAMP 1小鼠的短寿命和加速死亡。
Biochemical and genetic data suggest that the Apoa2c allele of the apolipoprotein A-II gene causes severe senile amyloidosis (AApoAII) in SAMP1, a mouse model for accelerated senescence. We analyzed the effects of replacement of Apoa2c in SAMP1 mice with non-amyloidogenic Apoa2b on amyloidosis, lipoprotein metabolism, and progression of senescence using a congenic strain, P1.R1-Apoa2b, which has the Apoa2b chromosome region of SAMR1 in the genome of SAMP1. Age-associated amyloid deposition was not observed, but plasma concentrations of apoA-II protein and HDL-cholesterol decreased with age in P1.R1-Apoa2b. P1.R1-Apoa2b showed lower scores of senescence than did SAMP1. However, the life span and mortality rate doubling time were similar in P1.R1-Apoa2b and SAMP1. These results suggest that replacement of Apoa2c with non-amyloidogenic Apoa2b does not rescue SAMP1 mice from a short life span and accelerated mortality.
影响载脂蛋白 A-II 翻译效率的多态性决定了高密度脂蛋白的大小和组成。
DOI：
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发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Doolittle,MH;LeBoeuf,RC;Warden,CH;Bee,LM;Lusis,AJ
通讯作者：
Lusis,AJ
小鼠脂质运输的遗传控制。
DOI：
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发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Lusis,AJ;Taylor,BA;Wangenstein,RW;LeBoeuf,RC
通讯作者：
LeBoeuf,RC