ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS.
ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS.
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DOI：
10.1084/jem.61.5.689
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发表时间：
1935-04-30
期刊：
影响因子：
--
通讯作者：
Schwentker FF
中科院分区：
文献类型：
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作者：
Rivers TM;Schwentker FF
重复肌肉注射的水乳液和酒精-乙醚提取物的无菌正常兔脑以某种方式产生的病理变化，伴随着髓鞘破坏的8只猴子（猕猴）的大脑中的7。8只，对照组猴子保持良好。从相关脑组织中提取的培养物保持无菌状态，通过将脑组织碎片的乳剂脑内接种到猴子、兔子、豚鼠和白色小鼠中，证明没有传染性因子。
The repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (Macacus rhesus). Eight, control monkeys remained well. Cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intracerebral inoculations of emulsions of bits of the brains into monkeys, rabbits, guinea pigs, and white mice.