Nitric oxide is a determinant of membrane fluidity of erythrocytes in postmenopausal women: an electron paramagnetic resonance investigation.
Nitric oxide is a determinant of membrane fluidity of erythrocytes in postmenopausal women: an electron paramagnetic resonance investigation.
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一氧化氮是绝经后妇女红细胞膜流动性的决定因素：电子顺磁共振研究。
DOI：
10.1016/s0895-7061(02)03261-2
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发表时间：
2003
影响因子：
3.2
通讯作者：
I. Nishio
中科院分区：
文献类型：
--
作者：
K. Tsuda;Yukiko Kinoshita;K. Kimura;I. Nishio
在本研究中，为了确定一氧化氮（NO）在膜功能调节中的可能作用，我们研究了绝经后妇女血浆一氧化氮水平与红细胞膜流动性之间的关系。我们通过电子顺磁共振（EPR）和自旋标记方法评估了从高血压和正常血压的绝经后妇女获得的红细胞的膜流动性。 EPR 研究表明，高血压绝经后女性的红细胞膜中 5-硝基氧硬脂酸酯的有序参数 (S) 显着高于血压正常的绝经后女性。研究结果表明，与血压正常的绝经后女性相比，高血压绝经后女性的红细胞膜流动性降低。高血压绝经后女性空腹时血浆一氧化氮代谢物（亚硝酸盐和硝酸盐）水平显着低于血压正常的绝经后女性。此外，红细胞膜EPR谱中的序参数（S）与血浆NO代谢物水平呈负相关，这表明绝经后女性红细胞膜流动性较低与血浆NO水平较低有关。这些结果与 NO 可能在绝经后妇女红细胞膜流动性调节中发挥关键作用的假设是一致的。 Am J Hypertens 2003；16:244–248 @ 2003 美国高血压杂志有限公司。
In the present study, to determine a possible role of nitric oxide (NO) in the regulation of membrane functions, we examined the relationship between plasma NO level and membrane fluidity of erythrocytes in postmenopausal women. We evaluated the membrane fluidity of erythrocytes obtained from hypertensive and normotensive postmenopausal women by means of an electron paramagnetic resonance (EPR) and spin labeling method. The EPR study revealed that the order parameter (S) for 5-nitroxide stearate in erythrocyte membranes was significantly greater in hypertensive postmenopausal women than in normotensive postmenopausal women. The finding indicated that the membrane fluidity of erythrocytes was decreased in hypertensive postmenopausal women compared with normotensive postmenopausal women. The plasma level of the NO metabolites (nitrite and nitrate) while fasting was significantly lower in hypertensive postmenopausal women than in normotensive postmenopausal women. In addition, the order parameter (S) in the EPR spectra of erythrocyte membranes was inversely correlated with the plasma NO metabolite level, which indicated that the lower membrane fluidity of erythrocytes was associated with the lower plasma NO level in postmenopausal women. These results are consistent with the hypothesis that NO may have a crucial role in the regulation of membrane fluidity of erythrocytes in postmenopausal women. Am J Hypertens 2003;16:244–248 @ 2003 American Journal of Hypertension, Ltd.
在高胰岛素血症高血压受试者中，钠-锂逆向转运对钠的亲和力较低。
DOI：
10.1161/01.hyp.25.5.986
发表时间：
1995
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Zerbini,G;Ceolotto,G;Gaboury,C;Mos,L;Pessina,AC;Canessa,M;Semplicini,A
通讯作者：
Semplicini,A
影响因子：
2.9
作者：
MARLETTA, MA;YOON, PS;WISHNOK, JS
通讯作者：
WISHNOK, JS