THE CHEMOTACTIC EFFECT OF PHLEBOTOMUS-DUBOSCQI (DIPTERA, PSYCHODIDAE) SALIVARY-GLAND LYSATES TO MURINE MONOCYTES
THE CHEMOTACTIC EFFECT OF PHLEBOTOMUS-DUBOSCQI (DIPTERA, PSYCHODIDAE) SALIVARY-GLAND LYSATES TO MURINE MONOCYTES
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DOI：
10.1016/0001-706x(95)00112-r
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发表时间：
1995-10-01
期刊：
影响因子：
2.7
通讯作者：
KOECH, DK
中科院分区：
文献类型：
--
作者：
ANJILI, CO;MBATI, PA;KOECH, DK
研究了杜氏白蛉唾液腺裂解液能够吸引脊椎动物单核细胞的可能性。体外研究表明，肯尼亚主要利什曼原虫载体杜波斯奇疟原虫的唾液腺裂解物对小鼠腹膜单核细胞具有趋化作用。载体唾液腺裂解物对单核细胞的吸引可能构成了白蛉唾液确保利什曼原虫寄生在易感宿主体内巨噬细胞成功寄生的部分机制。
The possibility that salivary gland lysates of Phlebotomus duboscqi are able to attract vertebrate monocytes was investigated. In vitro studies showed that salivary gland lysates of P. duboscqi, the vector of Leishmania major in Kenya, are chemotactic to mouse peritoneal monocytes. This attraction of monocytes by vector salivary gland lysates may form part of the mechanisms through which sandfly saliva ensures successful parasitization of macrophages in a susceptible host by Leishmania parasites.