Evaluation of methods for the prediction of membrane spanning regions
Evaluation of methods for the prediction of membrane spanning regions
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DOI：
10.1093/bioinformatics/17.7.646
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发表时间：
2001-07-01
期刊：
影响因子：
5.8
通讯作者：
Apweiler, R
中科院分区：
文献类型：
--
作者：
Möller, S;Croning, MDR;Apweiler, R
动机目前有多种工具可用于预测跨膜蛋白的拓扑结构。迄今为止，还没有发表过对这些工具性能的独立评估。更好地了解不同工具的优缺点将指导生物学家和生物信息学家更好地预测膜蛋白的拓扑结构：在此，我们对目前已知的、最广泛使用的蛋白质跨膜区域预测方法的性能进行了评估。结果表明，TMHMM 是目前性能最好的跨膜预测程序。
Motivation: A variety of tools are available to predict the topology of transmembrane proteins. To date no independent evaluation of the performance of these tools has been published. A better understanding of the strengths and weaknesses of the different tools would guide both the biologist and the bioinformatician to make better predictions of membrane protein topology.Results: Here we present an evaluation of the performance of the currently best known and most widely used methods for the prediction of transmembrane regions in proteins. Our results show that TMHMM is currently the best performing transmembrane prediction program.