Iron Accumulation and DNA Damage in a Pig Model of Intracerebral Hemorrhage
Iron Accumulation and DNA Damage in a Pig Model of Intracerebral Hemorrhage
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DOI：
10.1007/978-3-7091-0693-8_20
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Xi, Guohua
中科院分区：
文献类型：
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作者：
Gu, Yuxiang;Hua, Ya;Xi, Guohua
脑内铁超载导致大鼠和猪脑出血（ICH）后脑损伤。目前的研究检查了铁螯合剂，去铁胺，是否可以减少猪ICH诱导的DNA损伤。猪接受自体血液注射到右额叶。去铁胺（50 mg/kg，i.m.）或溶剂，然后每12小时给药一次，直至7天。在ICH后第3天或第7天处死动物，以检查铁积累和DNA损伤。我们发现，ICH导致了一个红色的血肿周围区的发展，在该区域内的铁积累和DNA损伤。去铁胺治疗减少了血肿周围的红色区，减少了Perls'细胞的数量（p
Cerebral iron overload causes brain injury after intracerebral hemorrhage (ICH) in rats and pigs. The current study examined whether an iron chelator, deferoxamine, can reduce ICH-induced DNA damage in pigs. Pigs received an injection of autologous blood into the right frontal lobe. Deferoxamine (50 mg/kg, i.m.) or vehicle was given 2 h after ICH and then every 12 h up to 7 days. Animals were killed at day 3 or day 7 after ICH to examine iron accumulation and DNA damage. We found that ICH resulted in the development of a reddish perihematomal zone, with iron accumulation and DNA damage within that zone. Deferoxamine treatment reduced the perihematomal reddish zone, and the number of Perls' (p