SENSORY CIRCUMVENTRICULAR ORGANS AND BRAIN HOMEOSTATIC PATHWAYS
SENSORY CIRCUMVENTRICULAR ORGANS AND BRAIN HOMEOSTATIC PATHWAYS
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DOI：
10.1096/fasebj.7.8.8500693
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发表时间：
1993-05-01
期刊：
影响因子：
4.8
通讯作者：
GROSS, PM
中科院分区：
文献类型：
--
作者：
JOHNSON, AK;GROSS, PM
脑室周围器官(CVO)是大脑中线上与脑室间隙接壤的小结构，具有共同的形态和内分泌样特征，将它们与神经系统的其他部分区分开来。它们的独特特征包括与血液和脑脊液两种液体相的细胞联系，以及与战略核团的神经联系，建立了贯穿神经轴的通讯电路。CVO的各种额外的形态和功能特征表明，这组结构参与了广泛的动态平衡过程。对于三个脑室周围器官-穹隆下器(SFO)、终板血管器(OVLT)和最后区(AP)-最近的发现表明，这些结构是血液信息到达大脑的目标。我们认为这三个感觉性CVO通过神经和体液联系与其他核团相互作用，维持几个动态平衡过程。我们强调大脑CVO在维持体液平衡方面的集体作用，作为中枢神经体液系统中这些迷人的“大脑之窗”的功能整合的模型。
Circumventricular organs (CVOs), small structures bordering the ventricular spaces in the midline of the brain, have common morphological and endocrine-like characteristics that distinguish them from the rest of the nervous system. Among their unique features are cellular contacts with two fluid phases - blood and cerebrospinal fluid - and neural connections with strategic nuclei establishing circuitry for communications throughout the neuraxis. A variety of additional morphological and functional characteristics of the CVOs implicates this group of structures in a wide array of homeostatic processes. For three of the circumventricular organs - the subfornical organ (SFO), the organum vasculosum of the lamina terminalis (OVLT), and the area postrema (AP) - recent findings demonstrate these structures as targets for blood-borne information reaching the brain. We propose that these three sensory CVOs interact with other nuclei in the maintenance of several homeostatic processes by way of neural and humoral links. We emphasize the collective role of brain CVOs in the maintenance of body fluid homeostasis as a model for the functional integration of these fascinating ''windows of the brain'' within central neurohumoral systems.