Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction
Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction
复制标题
激光散斑血流成像对左心室收缩和舒张功能障碍患者眼部微循环的脉搏波形分析
DOI：
10.1159/000494066
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发表时间：
2018
影响因子：
1.7
通讯作者：
Hori Yuichi
中科院分区：
文献类型：
--
作者：
Shiba Tomoaki;Takahashi Mao;Matsumoto Tadashi;Hori Yuichi
目的：(1) 激光散斑血流成像 (LSFG) 显示的眼部微循环脉搏波形分析的变量是否与左心室 (LV) 收缩功能障碍相关，以及 (2) 这些变量是否与经超声心动图评估无左心室收缩功能障碍的受试者的左心室舒张功能障碍相关。方法我们研究了 200 名连续受试者。当左心室射血分数< 50% 时，已确定存在左心室收缩功能障碍。当受试者的 E/e' 比率≥ 15 且 e' 速度 < 10 cm/s 时，即可诊断左室舒张功能障碍。我们使用LSFG评估了视神经乳头（ONH）和脉络膜的脉搏波形分析变量“上升率”和井喷评分（BOS）。 结果脑利钠肽（BNP）水平、脉络膜区域上升率（上升率-脉络膜）和心率被揭示为左室收缩功能障碍的独立因素，并且BOS-脉络膜被确定为左室舒张功能障碍的独立因素。左心室收缩功能障碍的 BNP 和脉络膜上升率曲线下面积 (AUC) 分别为 0.83 和 0.81。左室舒张功能障碍的BOS-脉络膜AUC为0.73。结论脉络膜脉搏波形分析与左室收缩和左室舒张功能具有显着相关性。
PurposeTo determine:(1) whether variables of a pulse wave form analysis of ocular microcirculation shown by laser speckle flowgraphy (LSFG) correlate with left ventricular (LV) systolic dysfunction and (2) whether these variables correlate with LV diastolic dysfunction in subjects without LV systolic dysfunction as assessed by echocardiography.MethodsWe studied 200 consecutive subjects. LV systolic dysfunction has been determined to be present when the LV ejection fraction was< 50%. LV diastolic dysfunction was diagnosed when subjects had an E/e’ratio≥ 15 and an e’velocity< 10 cm/s. We evaluated the pulse waveform analysis variables “rising rate” and the blowout score (BOS) using LSFG in the optic nerve head (ONH) and choroid.ResultsThe brain natriuretic peptide (BNP) level, the rising rate in the choroid area (rising rate-choroid), and heart rate were revealed as independent factors for LV systolic dysfunction, and BOS-choroid was identified as an independent factor for LV diastolic dysfunction. The areas under the curve (AUC) of BNP and rising rate-choroid for LV systolic dysfunction were 0.83 and 0.81, respectively. The AUC of BOS-choroid for LV diastolic dysfunction was 0.73.ConclusionPulse waveform analysis in the choroid has a significant correlation with LV systolic and LV diastolic function.