Regulation of the Immune System by Laminins.
Regulation of the Immune System by Laminins.
复制标题
层粘连蛋白对免疫系统的调节。
DOI：
10.1016/j.it.2017.06.002
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发表时间：
2017
影响因子：
16.8
通讯作者：
Bromberg,JonathanS
中科院分区：
文献类型：
--
作者：
Simon,Thomas;Bromberg,JonathanS
层粘连蛋白是三聚体蛋白，其是将内皮细胞和上皮细胞与下层组织分开的基底膜的主要组分。已经描述了16种层粘连蛋白同种型，每种具有不同的组织表达模式和功能。虽然层粘连蛋白具有关键的结构作用，但最近的证据也表明它们也影响免疫细胞的迁移和功能。层粘连蛋白在免疫或耐受时差异表达并定向免疫应答。本文综述了层粘连蛋白的结构、表达调控及其与免疫系统的相互作用。最后，将讨论层粘连蛋白在自身免疫性疾病和移植中的作用。
Laminins are trimeric proteins that are major components of the basement membranes that separate endothelia and epithelia from the underlying tissue. Sixteen laminin isoforms have been described, each with distinct tissue expression patterns and functions. While laminins have a critical structural role, recent evidence also indicates that they also impact the migration and functions of immune cells. Laminins are differentially expressed upon immunity or tolerance and orientate the immune response. This review will summarize the structure of laminins, the modulation of their expression, and their interactions with the immune system. Finally, the role of the laminins in autoimmune diseases and transplantation will be discussed.