Normal fasting plasma glucose levels and type 2 diabetes in young men
Normal fasting plasma glucose levels and type 2 diabetes in young men
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DOI：
10.1056/nejmoa050080
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发表时间：
2005-10-06
影响因子：
158.5
通讯作者：
Rudich, A
中科院分区：
文献类型：
--
作者：
Tirosh, A;Shai, I;Rudich, A
背景：最近将正常空腹血糖水平定义为低于 100 毫克每分升（5.55 毫摩尔每升）。该范围内较高的空腹血糖水平是否独立预测年轻人患 2 型糖尿病尚不清楚。 方法：我们从以色列国防军 26 至 45 岁的男性中获取了血液测量数据、体检数据以及医疗和生活方式信息。 结果：在 74,309 人年的随访期间（从 1992 年到 2004 年），总共发生了 208 例 2 型糖尿病病例。 13,163 名受试者的基线空腹血糖水平低于 100 毫克/分升。根据年龄、糖尿病家族史、体重指数、体力活动水平、吸烟状况和血清甘油三酯水平进行调整的多变量模型显示，与那些空腹血糖水平处于最低五分之一（低于 81 毫克每分升 [4.5 毫摩尔每升]）的男性相比，空腹血糖水平为 87 毫克每分升（4.83 毫摩尔每升）或更高的男性患 2 型糖尿病的风险逐渐增加，P 为趋势
BACKGROUND:The normal fasting plasma glucose level was recently defined as less than 100 mg per deciliter (5.55 mmol per liter). Whether higher fasting plasma glucose levels within this range independently predict type 2 diabetes in young adults is unclear.METHODS:We obtained blood measurements, data from physical examinations, and medical and lifestyle information from men in the Israel Defense Forces who were 26 to 45 years of age.RESULTS:A total of 208 incident cases of type 2 diabetes occurred during 74,309 person-years of follow-up (from 1992 through 2004) among 13,163 subjects who had baseline fasting plasma glucose levels of less than 100 mg per deciliter. A multivariate model, adjusted for age, family history of diabetes, body-mass index, physical-activity level, smoking status, and serum triglyceride levels, revealed a progressively increased risk of type 2 diabetes in men with fasting plasma glucose levels of 87 mg per deciliter (4.83 mmol per liter) or more, as compared with those whose levels were in the bottom quintile (less than 81 mg per deciliter [4.5 mmol per liter], P for trend