Evidence for altered synthesis of type II collagen in patients with osteoarthritis
Evidence for altered synthesis of type II collagen in patients with osteoarthritis
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DOI：
10.1172/jci4853
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发表时间：
1998-12-15
影响因子：
15.9
通讯作者：
Poole, AR
中科院分区：
文献类型：
--
作者：
Nelson, F;Dahlberg, L;Poole, AR
有证据表明，骨关节炎（OA）中II型胶原的合成增加。使用免疫测定，我们表明，内容的C-前肽的II型前胶原（CPII），释放细胞外的新合成的分子，是直接相关的健康和骨关节炎关节软骨中的这种分子的合成。在OA软骨中，CPII含量通常显著升高（平均7.6倍），特别是在中深层，达到新生儿含量的29.6%。合成也与OA中的总胶原II含量直接相关，表明其在维持胶原含量和软骨结构中的重要性。CPII从软骨中的释放与软骨含量直接相关。然而，OA软骨中CPII的增加并未反映在血清中，在血清中观察到显著降低。这些研究为OA患者体内II型前胶原合成的改变提供了证据。
There is evidence to suggest that the synthesis of type II collagen is increased in osteoarthritis (OA). Using an immunoassay, we show that the content of the C-propeptide of type II procollagen (CPII), released extracellularly from the newly synthesized molecule, is directly related to the synthesis of this molecule in healthy and osteoarthritic articular cartilages. In OA cartilage, CPII content is often markedly elevated (mean 7.6-fold), particularly in the mid and deep zones, reaching 29.6% of the content in newborn. Synthesis is also directly related to total collagen II content in OA, suggesting its importance in maintaining collagen content and cartilage structure. The release of CPII from cartilage is correlated directly with cartilage content. However, the increase in CPII in OA cartilage is not reflected in serum, where a significant reduction is observed. Together these studies provide evidence for alterations in procollagen II synthesis in vivo in patients with OA.