Perspective - ultrastructural analyses reflect the effects of sleep and sleep loss on neuronal cell biology.
Perspective - ultrastructural analyses reflect the effects of sleep and sleep loss on neuronal cell biology.
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DOI：
10.1093/sleep/zsac047
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发表时间：
2022-05-12
期刊：
影响因子：
5.6
通讯作者：
Aton, Sara J
中科院分区：
文献类型：
--
作者：
Wang, Lijing;Aton, Sara J
最近对果蝇和啮齿动物大脑神经元的电子显微镜分析表明，急性或慢性睡眠不足可以改变各种细胞器的结构，包括线粒体、细胞核和高尔基体。在这里，我们在睡眠剥夺大脑的生化发现的背景下讨论这些发现，以阐明这些形态变化如何与细胞器功能改变相关。综合来看，我们讨论了现有数据表明睡眠缺失（特别是慢性睡眠缺失）如何破坏转录、翻译、细胞内运输和新陈代谢等基本细胞过程。更好地理解这些影响将对理解睡眠的生物学重要性以及睡眠不足与神经病理学的关系产生广泛的影响。
Recent electron microscopic analyses of neurons in the Drosophila and rodent brain demonstrate that acute or chronic sleep loss can alter the structures of various organelles, including mitochondria, nucleus, and Golgi apparatus. Here, we discuss these findings in the context of biochemical findings from the sleep deprived brain, to clarify how these morphological changes may related to altered organelle function. We discuss how, taken together, the available data suggest that sleep loss (particularly chronic sleep loss) disrupts such fundamental cellular processes as transcription, translation, intracellular transport, and metabolism. A better understanding of these effects will have broad implications for understanding the biological importance of sleep, and the relationship of sleep loss to neuropathology.