Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid
Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid
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blaCTX-M-199 的遗传和功能表征，blaCTX-M-199 是一种新型他佐巴坦和舒巴坦抗性编码基因，位于带有 mcr-1 的接合型 IncI2 质粒中
DOI：
10.1128/aac.00562-17
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发表时间：
2017-07-01
影响因子：
4.9
通讯作者：
Chen, Sheng
中科院分区：
文献类型：
--
作者：
Cai, Jiachang;Cheng, Qipeng;Chen, Sheng
我们报告了一种新型CTX-M-199 β-内酰胺酶的遗传学和功能特性，该酶由在带有IncI 2的接合mcr-1质粒中发现的bla（CTX-M-64）变体基因编码，并对β-内酰胺酶抑制剂他唑巴坦和舒巴坦表现出耐药性。
We report the genetic and functional characterization of a novel CTX-M-199 beta-lactamase, which was encoded by a bla(CTX-M-64) variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to beta-lactamase inhibitors, tazobactam, and sulbactam.