Altered Functional Connectivity of Hypothalamus in Lifelong Premature Ejaculation Patients
Altered Functional Connectivity of Hypothalamus in Lifelong Premature Ejaculation Patients
复制标题
终生早泄患者下丘脑功能连接的改变
DOI：
10.1002/jmri.27099
复制
发表时间：
2020-09-01
影响因子：
4.4
通讯作者：
Liu, Peng
中科院分区：
文献类型：
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作者：
Gao, Ming;Feng, Nana;Liu, Peng
研究背景早泄（PE）是男性最常见的性功能障碍之一，常导致患者痛苦。下丘脑与健康男性的射精控制有关。然而，在这方面，我们不知道终身PE患者下丘脑相关的内在连接是否改变。目的研究终身PE患者与健康对照（HC）相比下丘脑的异常内在连接。研究类型使用患者和HC的横截面数据的前瞻性初步研究。受试者47例终身PE患者和30例HC被纳入本研究。场强/序列3.0T MRI扫描仪用于T-评价MRI数据的预处理和下丘脑种子功能连接（FC）计算采用DPABI4.1进行。采用SPM 12内的测试来检查终身PE患者与HC相比下丘脑内在连接的可能改变，包括焦虑和抑郁评分作为协变量（错误发现率校正，P
BackgroundAs one of the most prevalent sexual dysfunctions in men, lifelong premature ejaculation (PE) often leads to patient distress. The hypothalamus is implicated in the ejaculatory control of healthy males. However, we do not know whether the hypothalamus-related intrinsic connectivity is altered in lifelong PE patients.PurposeTo investigate abnormal intrinsic connectivity of the hypothalamus in lifelong PE patients compared with healthy controls (HCs).Study TypeProspective pilot study using cross-sectional data of patients and HCs.SubjectsForty-seven lifelong PE patients and 30 HCs were included in this study.Field Strength/Sequence3.0T MRI scanner for T-1-weighted imaging using spoiled gradient recalled echo sequence and functional imaging using a single-shot gradient recalled echo sequence.AssessmentPreprocessing of MRI data and hypothalamus-seeded functional connectivity (FC) computation were performed using DPABI4.1.Statistical TestsThe two-sample t-test within SPM12 was adopted to examine possible alterations of intrinsic connectivity of hypothalamus in lifelong PE patients compared with HCs including anxiety and depression scores as covariates (false discovery rate-corrected, P