Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders.
Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders.
复制标题
DOI：
10.1097/01.alc.0000179368.87886.76
复制
发表时间：
2005-09-01
期刊：
影响因子：
--
通讯作者：
Clark, Duncan B
中科院分区：
文献类型：
--
作者：
De Bellis, Michael D;Narasimhan, Anandhi;Clark, Duncan B
背景：在成人中，前额叶、丘脑和小脑损伤与过量乙醇摄入有关。由于这些大脑结构在青春期积极成熟，我们假设患有青少年酒精使用障碍的受试者与对照受试者相比，这些区域的大脑体积较小。因此，我们将患有青少年发作性酒精使用障碍（AUD，定义为 DSM-IV 酒精依赖或滥用）的青少年和年轻人的前额叶-丘脑-小脑测量值与社会人口统计学相似的对照受试者的测量值进行了比较。 方法：使用磁共振成像测量 14 名受试者（8 名男性，6 名男性）的前额叶皮层、丘脑和小脑体积。 女性）和 AUD（平均年龄，17.0+/-2.1 岁）和 28 名对照受试者（16 名男性，12 名女性；16.9+/-2.3 岁）。所有 AUD 受试者都是从药物滥用治疗计划中招募的，并且患有共存精神障碍。 结果：与对照受试者相比，患有酒精使用障碍的受试者的前额皮质和前额皮质白质体积较小。右侧、左侧和总丘脑、脑桥/脑干、右侧和左侧小脑半球、总小脑和小脑蚓部体积在各组之间没有差异。存在显着的逐组性别效应，表明与对照组男性相比，青少年发病的 AUD 男性的小脑体积较小，而两个女性组的小脑体积没有差异。前额叶皮层体积变量与饮酒量显着相关。结论：这些发现表明，较小的前额叶皮层与患有精神障碍的个体的早发性饮酒有关。需要进一步的研究来检验较小的前额皮质是否代表早发性饮酒的脆弱性或后果。
BACKGROUND: In adults, prefrontal, thalamic, and cerebellar brain injury is associated with excessive ethanol intake. As these brain structures are actively maturing during adolescence, we hypothesized that subjects with adolescent-onset alcohol use disorders, compared with control subjects, would have smaller brain volumes in these areas. Thus, we compared prefrontal-thalamic-cerebellar measures of adolescents and young adults with adolescent-onset alcohol use disorders (AUD, defined as DSM-IV alcohol dependence or abuse) with those of sociodemographically similar control subjects.METHODS: Magnetic resonance imaging was used to measure prefrontal cortex, thalamic, and cerebellar volumes in 14 subjects (eight males, six females) with an AUD (mean age, 17.0+/-2.1 years) and 28 control subjects (16 males, 12 females; 16.9+/-2.3 years). All AUD subjects were recruited from substance abuse treatment programs and had comorbid mental disorders.RESULTS: Subjects with alcohol use disorders had smaller prefrontal cortex and prefrontal cortex white matter volumes compared with control subjects. Right, left, and total thalamic, pons/brainstem, right and left cerebellar hemispheric, total cerebellar, and cerebellar vermis volumes did not differ between groups. There was a significant sex-by-group effect, indicating that males with an adolescent-onset AUD compared with control males had smaller cerebellar volumes, whereas the two female groups did not differ in cerebellar volumes. Prefrontal cortex volume variables significantly correlated with measures of alcohol consumption.CONCLUSIONS: These findings suggest that a smaller prefrontal cortex is associated with early-onset drinking in individuals with comorbid mental disorders. Further studies are warranted to examine if a smaller prefrontal cortex represents a vulnerability to, or a consequence of, early-onset drinking.