Chromosomal localization of a new mouse lens opacity gene (lop18)
Chromosomal localization of a new mouse lens opacity gene (lop18)
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DOI：
10.1006/geno.1996.0439
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发表时间：
1996-08-15
期刊：
影响因子：
4.4
通讯作者：
Roderick, TH
中科院分区：
文献类型：
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作者：
Chang, B;Hawes, NL;Roderick, TH
用裂隙灯和间接检眼镜检查小鼠品系显示，品系CBA/CaGnLe在断奶年龄时具有明显的白色白内障。它很快发展为一个大的白色核性白内障，伴有轻度皮质改变。与C57 BL/6 J杂交表明，这是作为一个单隐性完全外显基因遗传的，我们将其命名为lop 18（透镜不透明度18）。利用可见标记T（短尾畸形）、组织相容性标记H2和微卫星标记D17 Mit 21、D17 Mit 28、D17 Mit 38和D17 Mit 46进行的连锁分析表明，lop 18基因位于小鼠17号染色体上的着丝粒附近，距离16 cM。它是Lu晶体蛋白（Crya 1）基因的可能候选突变。(C)出版社：Academic Press，Inc.
Examination of mouse strains with a slit lamp and indirect ophthalmoscopy revealed that strain CBA/CaGnLe has a white cataract obvious at weaning age. It soon progresses to a large white nuclear cataract with mild cortical changes. Crosses with C57BL/6J showed that this is inherited as a single recessive fully penetrant gene, which we have designated lop18 (lens opacity 18). Linkage analysis using visible marker T (brachyury), histocompatibility marker H2, and microsatellite markers D17Mit21, D17Mit28, D17Mit38, and D17Mit46 shows that the lop18 gene is located, similar to 16 cM from the centromere on mouse Chromosome 17. It is a likely candidate mutation for the Lu crystallin (Crya1) gene. (C) 1996 Academic Press, Inc.