Activated photothermal heating using croconaine dyes
Activated photothermal heating using croconaine dyes
复制标题
DOI：
10.1039/c3sc51978c
复制
发表时间：
2013-01-01
期刊：
影响因子：
8.4
通讯作者：
Smith, Bradley D.
中科院分区：
文献类型：
--
作者：
Spence, Graeme T.;Hartland, Gregory V.;Smith, Bradley D.
激光诱导的光热加热是由染料或纳米颗粒促进的，它们强烈吸收光并将其转化为热。最著名的近红外吸收系统是金纳米棒和纳米笼。使用有机染料吸收激光的替代策略由于分子尺寸小和潜在的合成灵活性而具有几个固有的优点，但主要缺点是快速光热漂白。在这里，我们报告了三个重要的发现：(a)近红外大麻碱染料表现出优异的高性能光热加热性能；包括800nm左右的强而窄的吸收带，高的化学、光和热稳定性，非常有效的基态弛豫，以及非常低的氧光敏能力。(b)光热加热遵循比尔-朗伯定律（1 - 10(a)），当显色团吸光度值大于类似于1时，样品加热达到渐近极限。(c) Croconaine染料形成红移包封复合物，允许实现分子识别诱导的活化光热加热，这是一种广泛适用的纳米级设计概念，利用化学或超分子过程来开启激光诱导的热疗。
Laser-induced photothermal heating is promoted by dyes or nanoparticles that strongly absorb light and convert it into heat. The best known near-infrared absorbing systems are gold nanorods and nanocages. The alternative strategy of using organic dyes to absorb the laser light has several inherent advantages due to the small molecular size and potential synthetic flexibility, but a major drawback is rapid photothermal bleaching. Here, we report three important findings: (a) near-infrared croconaine dyes exhibit outstanding properties for high performance photothermal heating; including an intense and narrow absorption band at around 800 nm, high chemical, photo-and thermal stability, very efficient relaxation to the ground state, and very low oxygen photosensitization ability. (b) Photothermal heating obeys the Beer-Lambert law (1 - 10(-A)) and sample heating reaches an asymptotic limit when chromophore absorbance values are greater than similar to 1. (c) Croconaine dyes form red-shifted encapsulation complexes which allows the realization of molecular recognition induced activated photothermal heating, a broadly applicable nanoscale design concept that employs chemical or supramolecular processes to switch on laser-induced hyperthermia.