A three-dimensional model for arterial tree representation, generated by constrained constructive optimization
A three-dimensional model for arterial tree representation, generated by constrained constructive optimization
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DOI：
10.1016/s0010-4825(98)00045-6
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发表时间：
1999-01-01
影响因子：
7.7
通讯作者：
Schreiner, W
中科院分区：
文献类型：
--
作者：
Karch, R;Neumann, F;Schreiner, W
约束构造性优化（CCO）的计算方法在两个重要方面得到推广：（I）动脉模型树现在生长在一个凸？三维组织片和（2）终端可变性如何被结合到模型中以解释在真实的血管床中观察到的血液的异质性。尽管没有来自局部解剖学的直接信息进入模型，但是计算机生成的CCO树在视觉基础上和关于形态测量参数两者上都非常类似于真实的动脉树的腐蚀铸件。终端流的变化被发现诱导过渡的连接结构的早期树木的发展。目前的推广CCO提供-第一次-可能性，以生成优化的动脉模型树在三维，代表一个现实的几何基板的血流动力学模拟研究。随着终端流量可变性的实施，该模型准备模拟过程，如适应动脉直径的血液流速的变化或形成不同的模式的血管生成引起的血液供应的需求变化。(C)1999 Elsevier Science Ltd.保留所有权利。
The computational method of constrained constructive optimization (CCO) has been generalized in two important respects: (I) arterial model trees are now grown within a convex? three-dimensional piece of tissue and (2) terminal how variability has been incorporated into the model to account for the heterogeneity of blood how observed in real vascular beds, Although no direct information from topographic anatomy enters the model, computer-generated CCO trees closely resemble corrosion casts of real arterial trees, both on a visual basis and with regard to morphometric parameters. Terminal flow variability was found to induce transitions in the connective structure early in the trees' development. The present generalization of CCO offers - for the first time - the possibility to generate optimized arterial model trees in three dimensions, representing a realistic geometrical substrate for hemodynamic simulation studies. With the implementation of terminal flow variability the model is ready to simulate processes such as the adaptation of arterial diameters to changes in blood flow rate or the formation of different patterns of angiogenesis induced by changing needs of blood supply. (C) 1999 Elsevier Science Ltd. All rights reserved.