Genetic determinants of vascular reactivity
Genetic determinants of vascular reactivity
复制标题
血管反应性的遗传决定因素
DOI：
10.1007/s11906-002-0052-z
复制
发表时间：
2002
影响因子：
5.6
通讯作者：
B. I. Lévy
中科院分区：
文献类型：
--
作者：
D. Henrion;J. Bénessiano;M. Iglarz;I. Philip;B. I. Lévy
Blood pressure is controlled by a complex combination of processes that influence cardiac output and peripheral vascular resistance. Multiple genes potentially influence each parameter involved in the control of blood pressure, and individuals with the same blood pressor level do not necessarily have the same genotype at relevant loci, nor do individuals with the same genotype at particular loci necessarily have the same blood pressure. Nevertheless, pharmacogenetic studies of vascular reactivity will certainly allow the analysis of the mechanisms affected by genes, and lead to a better understanding of the epidemiologic observations seen in large groups of patients. Polymorphisms in the genes of the renin-angiotensin system allow definition of the “genetic profile” associated with a higher risk of cardiovascular disease, and can also be linked to significant changes in vascular reactivity in arteries isolated from patients carrying the polymorphisms.
具有重要功能的 β2 肾上腺素受体多态性的频率在非洲裔美国人、白人和中国人中存在显着差异。
DOI：
--
发表时间：
1999
期刊：
Pharmacogenetics
影响因子：
--
作者：
Xie,HG;Stein,CM;Kim,RB;Xiao,ZS;He,N;Zhou,HH;Gainer,JV;Brown,NJ;Haines,JL;Wood,AJ
通讯作者：
Wood,AJ
血管紧张素 II 放大动脉对去甲肾上腺素的收缩反应而不增加 Ca 内流：蛋白激酶 C 的作用。
DOI：
--
发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Henrion,D;Laher,I;Laporte,R;Bevan,JA
通讯作者：
Bevan,JA