Sensitive skin: closing in on a physiological cause
Sensitive skin: closing in on a physiological cause
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DOI：
10.1111/j.1600-0536.2009.01697.x
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发表时间：
2010-01-01
影响因子：
5.5
通讯作者：
Maibach, Howard I.
中科院分区：
文献类型：
--
作者：
Farage, Miranda A.;Maibach, Howard I.
“敏感皮肤”是最近才出现的一种现象，在使用化妆品（个人护理）产品后，某些人报告的不良感觉反应比正常人更强烈、更频繁。敏感性皮肤最初被定义为少数人的抱怨，现在工业化国家的大多数女性和近一半的男性都声称自己有敏感性皮肤。敏感皮肤是自我诊断的，通常没有任何明显的身体刺激迹象，随着针对这一不常见群体的消费品数量的增加，声称敏感皮肤的人数也在稳步上升。因此，许多皮肤科医生认为，这是一个“公主和豌豆”现象，敏感皮肤的问题在很大程度上避免了集中研究。然而，在过去几年中，与这种疾病的主要感觉症状相关的可记录的生物物理变化的证据已经积累起来，包括通过改进识别皮肤刺激亚临床体征的方法获得的一些证据。虽然对这种现象的病因学的理解尚不完整，但现有的研究现在支持这种疾病的生物物理起源。需要有效的诊断方法，神经敏感性夸大的内在和外在因素，以及与依从性相关的不适的具体机制，以及适当的预防和治疗手段。
The phenomenon of 'sensitive skin' is a relatively recent complaint in which certain individuals report more intense and frequent adverse sensory effects than the normal population upon use of cosmetic (personal-care) products. Originally defined as a minority complaint, sensitive skin is now claimed by a majority of women in industrialized countries and nearly half of men. Sensitive skin is self-diagnosed and typically unaccompanied by any obvious physical signs of irritation, and the number of individuals who claim sensitivity has risen steadily with the number of consumer products targeted towards this supposedly uncommon group. Believed by many dermatologists, therefore, to be a 'princess and the pea' phenomenon, the problem of sensitive skin has largely avoided focussed research. Over the last few years, however, the evidence of documentable biophysical changes associated with the largely sensory symptoms of this disorder has accumulated, including some gained by improved methods of identifying subclinical signs of skin irritation. Although the understanding of the aetiology of this phenomenon is as yet incomplete, existing research now supports a biophysical origin for this disorder. Effective methods of diagnosis, intrinsic and extrinsic contributors to exaggerated neural sensitivity, and the specific mechanisms of the discomfort associated with the compliant are required, as are appropriate means of prevention and treatment.