Effect of danazol on cyclosporine pharmacokinetics.
Effect of danazol on cyclosporine pharmacokinetics.
复制标题
达那唑对环孢素药代动力学的影响。
DOI：
10.1097/00007890-198805000-00038
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发表时间：
1988
期刊：
影响因子：
6.2
通讯作者：
Starzl,TE
中科院分区：
文献类型：
--
作者：
Koneru,B;Hartner,C;Iwatsuki,S;Starzl,TE
Danazol, a derivative of ethisterone is an inhibitor of pituitary gonadotrophins and a weak androgen. It is increasingly used in endometriosis and fibrocystic mastopathy. There has been only a single report of its effect on cyclosporine (CsA*) pharmacokinetics in a kidney transplant recipient in the literature in English (1).One of our patients, a 47-year-old woman with primary biliary cirrhosis, received an orthotopic liver transplant in January 1986. The patient began having irregular heavy vaginal bleeding in April 1986. At this time, she was taking CsA 150 mg pobid; prednisone 10 mg qd, azathioprine 25 mg qd, and lasix 40 mg qd She was placed on intermittent norethindrone (Norlutate) 15 mg poqd This did not have any effect on her vaginal bleeding, cyclosporine levels, or liver functions over a period of 3 months. The patient was eventually started on danazol 200 mg poqid Within days of starting danazol her CsA levels increased, along with a rise in transaminase values. There was no change in bilirubin and alkaline phosphatase levels (Table 1). After stopping danazol, CsA, transaminases, and creatinine levels reached previous values_ The rise in CsA levels could reflect increased intestinal absorption or decreased breakdown in the liver. There have been reports of inhibition by some sex steroids of hepatic microsomal enzyme systems (2) that increases CsA levels_ It is more than likely that the rise in CsA levels seen in our patient is a result of a decrease in CsA breakdown by the liver rather than increased absorption. In a series of nontransplant patients danazol has been reported to cause elevation of hepatic trans-
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影响因子：
3.6
作者：
ROBINSON, BH;TAYLOR, J;SHERWOOD, WG
通讯作者：
SHERWOOD, WG
影响因子：
4.1
作者：
C. Hoppel;C. Cooper
通讯作者：
C. Cooper
影响因子：
4.1
作者：
CHAPPELL, JB
通讯作者：
CHAPPELL, JB
1 号染色体上富马酸水合酶和鸟苷酸激酶基因以及 11 号染色体上溶酶体酸性磷酸酶和酯酶 A4 基因的区域分配。
DOI：
--
发表时间：
1976
期刊：
Birth defects original article series
影响因子：
--
作者：
N. Busby;J. Courval;U. Francke
通讯作者：
U. Francke
人体有机酸
影响因子：
5.2
作者：
R. Chalmers;A. M. Lawson
通讯作者：
A. M. Lawson